PMID- 24495461 OWN - NLM STAT- MEDLINE DCOM- 20160609 LR - 20220129 IS - 1873-2402 (Electronic) IS - 0006-3223 (Print) IS - 0006-3223 (Linking) VI - 78 IP - 8 DP - 2015 Oct 15 TI - The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity. PG - 554-62 LID - S0006-3223(14)00005-5 [pii] LID - 10.1016/j.biopsych.2013.12.015 [doi] AB - BACKGROUND: The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. METHODS: In a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling and seed-based resting state functional connectivity (RSFC) were used to produce spatial maps displaying changes in cerebral blood flow (CBF) and RSFC after MDMA administration. Participants underwent two arterial spin labeling and two blood oxygen level-dependent scans in a 90-minute scan session; MDMA and placebo study days were separated by 1 week. RESULTS: Marked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and hippocampus correlated with ratings of the intensity of global subjective effects of MDMA. The RSFC results complemented the CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex, and MTL regions, and increases between the amygdala and hippocampus. There were trend-level correlations between these effects and ratings of intense and positive subjective effects. CONCLUSIONS: The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug's characteristic subjective effects arise from its modulation of spontaneous brain activity. CI - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Carhart-Harris, Robin L AU - Carhart-Harris RL AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. Electronic address: r.carhart-harris@imperial.ac.uk. FAU - Murphy, Kevin AU - Murphy K AD - Cardiff University Brain Research Imaging Centre (KM), School of Psychology, Cardiff University, Cardiff, London, United Kingdom. FAU - Leech, Robert AU - Leech R AD - Division of Brain Sciences, Faculty of Medicine. FAU - Erritzoe, David AU - Erritzoe D AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Wall, Matthew B AU - Wall MB AD - Institute of Neurology (MBW),; Imanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London. FAU - Ferguson, Bart AU - Ferguson B AD - Clinical Psychopharmacology Unit (BF, LS, CM, HVC), University College London, London; University College London, London. FAU - Williams, Luke T J AU - Williams LT AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Roseman, Leor AU - Roseman L AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Brugger, Stefan AU - Brugger S AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - De Meer, Ineke AU - De Meer I AD - Imanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London. FAU - Tanner, Mark AU - Tanner M AD - Imanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London. FAU - Tyacke, Robin AU - Tyacke R AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Wolff, Kim AU - Wolff K AD - School of Biomedical Sciences (KW), Kings College London, London, United Kingdom. FAU - Sethi, Ajun AU - Sethi A AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Bloomfield, Michael A P AU - Bloomfield MA AD - Psychiatric Imaging Group (MAPB), MRC Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London. FAU - Williams, Tim M AU - Williams TM AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Bolstridge, Mark AU - Bolstridge M AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. FAU - Stewart, Lorna AU - Stewart L AD - Clinical Psychopharmacology Unit (BF, LS, CM, HVC), University College London, London; University College London, London. FAU - Morgan, Celia AU - Morgan C AD - Clinical Psychopharmacology Unit (BF, LS, CM, HVC), University College London, London; University College London, London. FAU - Newbould, Rexford D AU - Newbould RD AD - Imanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London. FAU - Feilding, Amanda AU - Feilding A AD - The Beckley Foundation (AF), Beckley Park, Oxford. FAU - Curran, H Val AU - Curran HV AD - Clinical Psychopharmacology Unit (BF, LS, CM, HVC), University College London, London; University College London, London. FAU - Nutt, David J AU - Nutt DJ AD - Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - 090199/WT_/Wellcome Trust/United Kingdom GR - MR/J00460X/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140110 PL - United States TA - Biol Psychiatry JT - Biological psychiatry JID - 0213264 RN - 0 (Serotonin Agents) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) RN - S88TT14065 (Oxygen) SB - IM CIN - Biol Psychiatry. 2015 Oct 15;78(8):519-21. PMID: 26386625 MH - Adult MH - Affect/*physiology MH - Amygdala/*drug effects MH - Cerebrovascular Circulation/drug effects MH - Double-Blind Method MH - Female MH - Healthy Volunteers MH - Hippocampus/drug effects MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage MH - Oxygen/*blood MH - Prefrontal Cortex/drug effects MH - Serotonin Agents/*administration & dosage MH - Temporal Lobe/drug effects MH - Young Adult PMC - PMC4578244 MID - EMS60193 OID - NLM: EMS60193 OTO - NOTNLM OT - 5-HT OT - Amygdala OT - Hippocampus OT - MDMA OT - PTSD OT - Serotonin OT - fMRI EDAT- 2014/02/06 06:00 MHDA- 2016/06/10 06:00 PMCR- 2015/10/15 CRDT- 2014/02/06 06:00 PHST- 2013/08/27 00:00 [received] PHST- 2013/12/05 00:00 [revised] PHST- 2013/12/16 00:00 [accepted] PHST- 2014/02/06 06:00 [entrez] PHST- 2014/02/06 06:00 [pubmed] PHST- 2016/06/10 06:00 [medline] PHST- 2015/10/15 00:00 [pmc-release] AID - S0006-3223(14)00005-5 [pii] AID - 10.1016/j.biopsych.2013.12.015 [doi] PST - ppublish SO - Biol Psychiatry. 2015 Oct 15;78(8):554-62. doi: 10.1016/j.biopsych.2013.12.015. Epub 2014 Jan 10.