PMID- 24495764
OWN - NLM
STAT- MEDLINE
DCOM- 20140904
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 51
IP  - 12
DP  - 2013 Dec
TI  - [Six Kawasaki disease patients with acute coronary artery thrombosis].
PG  - 925-9
AB  - OBJECTIVE: To improve the awareness of acute coronary artery thrombosis in 
      Kawasaki disease (KD). METHOD: Six KD patients with acute coronary artery 
      thrombosis (Jan. 2004 to Jan. 2013) were studied retrospectively. The basic 
      information, clinical manifestations, laboratory data, echocardiography and 
      electrocardiography (ECG), method and consequence of thrombolytic therapy were 
      analyzed. RESULT: The mean age of patients with coronary artery thrombosis (5 
      males and 1 female) was (17.2 +/- 11.3) months.Five cases had thrombosis in left 
      coronary artery (LCA), and four cases had thrombosis in aneurysm of left anterior 
      descending artery (LAD). One case had thrombosis in both left and right coronary 
      artery (RCA).One case died. Maximum thrombus was about 1.60 cm x 0.80 cm, 
      locating in LAD. The diameter of LCA and RCA was (0.44 +/- 0.07) cm and (0.45 +/- 
      0.07) cm. Two patients showed abnormal ECG. Case 3 showed ST segment depression 
      in lead V5. Case 6 showed myocardial infarction.In acute phase of KD, three 
      patients received treatment with intravenous immunoglobin (IVIG), five patients 
      were treated with aspirin.In sub-acute and convalescent phase of KD, all patients 
      were treated with low-dose aspirin.Warfarin and dipyridamole were applied in 5 
      patients. All cases were treated with thrombolytic therapy using urokinase and/or 
      heparin. After thrombolytic therapy, echocardiography showed thrombolysis in four 
      cases and no change in one.One patient died of myocardial infarction. CONCLUSION: 
      Most of acute coronary thrombosis in KD occurred in LAD. KD patients with 
      coronary artery thrombosis are at risk of sudden death due to myocardial 
      infarction.
FAU - Zhou, Shu-lai
AU  - Zhou SL
AD  - Department of Cardiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310003, China.
FAU - Luo, Jian-ping
AU  - Luo JP
AD  - Department of Cardiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310003, China.
FAU - Qi, Yan-qi
AU  - Qi YQ
AD  - Department of Cardiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310003, China.
FAU - Liang, Yu-guang
AU  - Liang YG
AD  - Department of Cardiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310003, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Cardiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310003, China.
FAU - Gong, Fang-qi
AU  - Gong FQ
AD  - Department of Cardiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310003, China. Email: gongfangqi@zju.edu.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
RN  - 0 (Anticoagulants)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acute Disease
MH  - Anticoagulants/administration & dosage/therapeutic use
MH  - Aspirin/administration & dosage/therapeutic use
MH  - Child, Preschool
MH  - Coronary Aneurysm/diagnosis/drug therapy/etiology
MH  - Coronary Thrombosis/diagnosis/*drug therapy/*etiology
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Fibrinolytic Agents/administration & dosage/*therapeutic use
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/therapeutic use
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*complications/drug therapy
MH  - Myocardial Infarction/diagnosis/etiology/mortality
MH  - Retrospective Studies
EDAT- 2014/02/06 06:00
MHDA- 2014/09/05 06:00
CRDT- 2014/02/06 06:00
PHST- 2014/02/06 06:00 [entrez]
PHST- 2014/02/06 06:00 [pubmed]
PHST- 2014/09/05 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2013 Dec;51(12):925-9.