PMID- 2449619
OWN - NLM
STAT- MEDLINE
DCOM- 19880329
LR  - 20131121
IS  - 1046-9516 (Print)
IS  - 1046-9516 (Linking)
VI  - 76
DP  - 1987
TI  - The effects of amphetamine-like designer drugs on monoaminergic systems in rat 
      brain.
PG  - 316-21
AB  - The response of brain dopaminergic and serotonergic systems to the 
      amphetamine-like designer drugs, 3,4-methylenedioxyamp amphetamine (MDA) and 
      3,4-methylenedioxymethamphetamine (MDMA), was investigated and compared to 
      methamphetamine (METH). Like METH, single or multiple doses of either drug caused 
      marked reductions in both tryptophan hydroxylase (TPH) activity and 
      concentrations of 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid 
      (5HIAA) in several brain regions. The reduction in 5HT content corresponded to 
      the depression of TPH activity in all regions examined. In contrast to METH, 
      which induced pronounced deficits in dopaminergic neuronal markers, repeated 
      doses of MDA or MDMA did not alter striatal tyrosine hydroxylase (TH) activities 
      or reduce striatal dopamine concentrations. A single dose of MDA or MDMA 
      significantly elevated striatal dopamine content; however, after repeated drug 
      administrations dopamine concentrations were comparable to control values. The 
      effects of MDA or MDMA administration in the rat brain are reminiscent of those 
      elicited by p-chloroamphetamine, a presumed serotonergic neurotoxin.
FAU - Gibb, J W
AU  - Gibb JW
AD  - University of Utah, Salt Lake City.
FAU - Stone, D M
AU  - Stone DM
FAU - Stahl, D C
AU  - Stahl DC
FAU - Hanson, G R
AU  - Hanson GR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - NIDA Res Monogr
JT  - NIDA research monograph
JID - 8811762
RN  - 0 (Amphetamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Brain/*drug effects/enzymology/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/metabolism
MH  - Tryptophan Hydroxylase/metabolism
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - NIDA Res Monogr. 1987;76:316-21.