PMID- 24498389
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - Abnormal intrinsic brain activity patterns in patients with subcortical ischemic 
      vascular dementia.
PG  - e87880
LID - 10.1371/journal.pone.0087880 [doi]
LID - e87880
AB  - OBJECTIVES: To investigate the amplitude of low-frequency fluctuations (ALFF) 
      alteration of whole brain in patients with subcortical ischemic vascular dementia 
      (SIVD). MATERIALS AND METHODS: Thirty patients with SIVD and 35 control subjects 
      were included in this study. All of them underwent structural MRI and rs-fMRI 
      scan. The structural data were processed using the voxel-based morphometry 8 
      toolbox (VBM8). The rs-fMRI data were processed using Statistical Parametric 
      Mapping (SPM8) and Data Processing Assistant for Resting-State fMRI (DPARSF) 
      software. Within-group analysis was performed with a one-sample Student's t-test 
      to identify brain regions with ALFF value larger than the mean. Intergroup 
      analysis was performed with a two-sample Student's t-test to identify ALFF 
      differences of whole brain between SIVD and control subjects. Partial 
      correlations between ALFF values and Montreal Cognitive Assessment (MoCA) and 
      Mini-Mental State Examination (MMSE) scores were analyzed in the SIVD group 
      across the parameters of age, gender, years of education, and GM volume. RESULTS: 
      Within-group analysis showed that the bilateral anterior cingulate cortex (ACC), 
      posterior cingulate cortex, medial prefrontal cortex (MPFC), inferior parietal 
      lobe (IPL), occipital lobe, and adjacent precuneus had significantly higher 
      standardized ALFF values than the global mean ALFF value in both groups. Compared 
      to the controls, patients with SIVD presented lower ALFF values in the bilateral 
      precuneus and higher ALFF values in the bilateral ACC, left insula and 
      hippocampus. Including GM volume as an extra covariate, the ALFF inter-group 
      difference exhibited highly similar spatial patterns to those without GM volume 
      correcting. Close negative correlations were found between the ALFF values of 
      left insula and the MoCA and MMSE scores of SIVD patients. CONCLUSION: SIVD is 
      associated with a unique spontaneous aberrant activity of rs-fMRI signals, and 
      measurement of ALFF in the precuneus, ACC, insula, and hippocampus may aid in the 
      detection of SIVD.
FAU - Liu, Chen
AU  - Liu C
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Li, Chuanming
AU  - Li C
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Yin, Xuntao
AU  - Yin X
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Zhou, Daiquan
AU  - Zhou D
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Gui, Li
AU  - Gui L
AD  - Department of Neurology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140203
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*physiopathology
MH  - Brain Ischemia/*physiopathology
MH  - *Brain Mapping
MH  - Case-Control Studies
MH  - Cerebral Cortex/*pathology
MH  - Dementia, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
PMC - PMC3912127
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/02/06 06:00
MHDA- 2014/10/21 06:00
PMCR- 2014/02/03
CRDT- 2014/02/06 06:00
PHST- 2013/08/01 00:00 [received]
PHST- 2014/01/04 00:00 [accepted]
PHST- 2014/02/06 06:00 [entrez]
PHST- 2014/02/06 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
PHST- 2014/02/03 00:00 [pmc-release]
AID - PONE-D-13-31504 [pii]
AID - 10.1371/journal.pone.0087880 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 3;9(2):e87880. doi: 10.1371/journal.pone.0087880. eCollection 
      2014.