PMID- 24498831
OWN - NLM
STAT- MEDLINE
DCOM- 20140227
LR  - 20190907
IS  - 1028-8880 (Print)
IS  - 1028-8880 (Linking)
VI  - 16
IP  - 16
DP  - 2013 Aug 15
TI  - An MTHFR variant, plasma homocysteine levels and late-onset coronary artery 
      disease in subjects from southern Iran.
PG  - 788-95
AB  - There have been many controversial debates on the role of Hyperhomocysteinaemia 
      (HHcy) as an independent risk factor for Coronary Artery Disease (CAD) during 
      recent years. Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd 
      amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been 
      considered as a factor that could render this enzyme thermolabile and less active 
      which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) 
      levels. To assess whether this polymorphism is associated with increased risk of 
      CAD and plasma levels of tHcy in a population from southern Iran, a total of 457 
      patients with angiographically documented multi-vessel CAD were compared with a 
      control group comprised of 371 subjects with <30% stenosis in all major vessels. 
      Nevertheless our results failed to admit a significant difference between CAD 
      individuals and control subjects for Ala/Val polymorphism and plasma Hcy 
      concentrations. However, plasma Hcy concentrations were significantly higher in 
      individuals with Val/Val genotype than subjects with Ala/Ala genotype, but it 
      didn't show a significant association with CAD in our population. Moreover, as 
      the multiple linear regression analysis indicated, smoking habit, folate levels 
      and the MTHFR Val/Val genotype were the only major predictors of tHcy 
      concentrations in the current investigation.
FAU - Saffari, Babak
AU  - Saffari B
AD  - Iranian Academic Center for Education, Culture and Research (ACECR), Fars 
      Province Branch, Shiraz 71347, Iran.
FAU - Senemar, Sara
AU  - Senemar S
AD  - Iranian Academic Center for Education, Culture and Research (ACECR), Fars 
      Province Branch, Shiraz 71347, Iran.
FAU - Karimi, Mehran
AU  - Karimi M
AD  - Hematology Research Center, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz 71937, Iran.
FAU - Bahari, Marzieh
AU  - Bahari M
AD  - Iranian Academic Center for Education, Culture and Research (ACECR), Fars 
      Province Branch, Shiraz 71347, Iran.
FAU - Jooyan, Najmeh
AU  - Jooyan N
AD  - Iranian Academic Center for Education, Culture and Research (ACECR), Fars 
      Province Branch, Shiraz 71347, Iran.
FAU - Yavarian, Majid
AU  - Yavarian M
AD  - Hematology Research Center, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz 71937, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Pakistan
TA  - Pak J Biol Sci
JT  - Pakistan journal of biological sciences : PJBS
JID - 101247723
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - Coronary Angiography
MH  - Coronary Artery Disease/blood/diagnostic 
      imaging/enzymology/epidemiology/*genetics
MH  - Coronary Stenosis/blood/diagnostic imaging/enzymology/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnostic imaging/enzymology/epidemiology/*genetics
MH  - Iran/epidemiology
MH  - Linear Models
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2014/02/07 06:00
MHDA- 2014/02/28 06:00
CRDT- 2014/02/07 06:00
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2014/02/28 06:00 [medline]
AID - 10.3923/pjbs.2013.788.795 [doi]
PST - ppublish
SO  - Pak J Biol Sci. 2013 Aug 15;16(16):788-95. doi: 10.3923/pjbs.2013.788.795.