PMID- 24498993
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20220419
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 6
DP  - 2013 Dec
TI  - HLA alleles and HLA-B27 haplotypes associated with susceptibility and severity of 
      ankylosing spondylitis in a Portuguese population.
PG  - 374-9
LID - 10.1111/tan.12238 [doi]
AB  - Human leukocyte antigen (HLA)-B27 is the mostly known major histocompatibility 
      complex (MHC) gene associated with ankylosing spondylitis (AS). Nonetheless, 
      there is substantial evidence that other MHC genes appear to be associated with 
      the disease, although it has not yet been established whether these associations 
      are driven by direct associations or by linkage disequilibrium (LD) mechanisms. 
      We aimed to investigate the contributions of HLA class I and II alleles and 
      B27-haplotypes for AS in a case-control study. A total of 188 HLA-B27 AS cases 
      and 189 HLA-B27 healthy controls were selected and typed for HLA class I and II 
      by the Luminex polymerase chain reaction-sequence specific oligonucleotide probe 
      (PCR-SSOP) method. Allelic and haplotypic distributions were estimated by maximum 
      likelihood method using Arlequin v3.11 and statistical analysis were performed by 
      Stata10.1. No associations were found between non-HLA-B27 loci and AS 
      susceptibility, but several associations were observed for phenotypic features of 
      the disease. DRB1*08 was identified as a risk factor for uveitis and DQB1*04 
      seems to provide protection for AS severity (functional, metrological and 
      radiological indexes). A*02/B27/C*02/DRB1*01/DQB1*05 [P<0.0001; odds ratio 
      (OR) = 39.06; 95% confidence interval (CI) (2.34-651)] is the only haplotype that 
      seems to confer susceptibility to AS. Moreover, the haplotype 
      A*02/B27/C*01/DRB1*08/DQB1*04 seems to provide protection for disease functional 
      and radiological repercussions. Our findings are compatible with the hypothesis 
      that other genes within the HLA region besides HLA-B27 might play some role in AS 
      susceptibility and severity.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Pimentel-Santos, F M
AU  - Pimentel-Santos FM
AD  - CEDOC, Faculdade de Ciencias Medicas da Universidade Nova de Lisboa, Lisbon, 
      Portugal; Centro Hospitalar Lisboa Ocidental (CHLO), Hospital de Egas Moniz, EPE, 
      Lisbon, Portugal.
FAU - Matos, M
AU  - Matos M
FAU - Ligeiro, D
AU  - Ligeiro D
FAU - Mourao, A F
AU  - Mourao AF
FAU - Ribeiro, C
AU  - Ribeiro C
FAU - Costa, J
AU  - Costa J
FAU - Santos, H
AU  - Santos H
FAU - Barcelos, A
AU  - Barcelos A
FAU - Pinto, P
AU  - Pinto P
FAU - Cruz, M
AU  - Cruz M
FAU - Sousa, E
AU  - Sousa E
FAU - Santos, R A
AU  - Santos RA
FAU - Fonseca, J E
AU  - Fonseca JE
FAU - Trindade, H
AU  - Trindade H
FAU - Guedes-Pinto, H
AU  - Guedes-Pinto H
FAU - Branco, J C
AU  - Branco JC
CN  - CORPOREA Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A*02 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
RN  - 0 (HLA-DRB1*08:01 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-A2 Antigen/genetics
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Portugal
MH  - Spondylitis, Ankylosing/*genetics/*immunology
MH  - Young Adult
OTO - NOTNLM
OT  - B27-haplotypes
OT  - HLA alleles
OT  - HLA class I and II
OT  - ankylosing spondylitis
OT  - phenotypic features
FIR - Mourao, A F
IR  - Mourao AF
FIR - de Matos, A A
IR  - de Matos AA
FIR - Ribeiro, C
IR  - Ribeiro C
FIR - Pimentel-Santos, F M
IR  - Pimentel-Santos FM
FIR - Pimentao Bravo, J
IR  - Pimentao Bravo J
FIR - Branco, J C
IR  - Branco JC
FIR - Mateus, M
IR  - Mateus M
FIR - Nero, P
IR  - Nero P
FIR - Araujo, P
IR  - Araujo P
FIR - Falcao, S
IR  - Falcao S
FIR - Pinto, T L
IR  - Pinto TL
FIR - Castelao, W
IR  - Castelao W
FIR - Vieira de Sousa, E
IR  - Vieira de Sousa E
FIR - Caetano-Lopes, J
IR  - Caetano-Lopes J
FIR - Fonseca, J E
IR  - Fonseca JE
FIR - Silva, C
IR  - Silva C
FIR - Simoes, E
IR  - Simoes E
FIR - Madeira, H
IR  - Madeira H
FIR - Santos, H
IR  - Santos H
FIR - Vaz Patto, J
IR  - Vaz Patto J
FIR - Ferreira, J
IR  - Ferreira J
FIR - Micaelo, M
IR  - Micaelo M
FIR - Mediavilla, M J
IR  - Mediavilla MJ
FIR - Sousa, M
IR  - Sousa M
FIR - Soares Branco, P
IR  - Soares Branco P
FIR - Godinho, F
IR  - Godinho F
FIR - Canas da Silva, J
IR  - Canas da Silva J
FIR - Garces, S
IR  - Garces S
FIR - Tavares, V
IR  - Tavares V
FIR - Ribeiro, A
IR  - Ribeiro A
FIR - Araujo, D
IR  - Araujo D
FIR - Costa, J A
IR  - Costa JA
FIR - Costa, L
IR  - Costa L
FIR - Afonso, M C
IR  - Afonso MC
FIR - Bogas, M
IR  - Bogas M
FIR - Alcino, S
IR  - Alcino S
FIR - Pinto, P
IR  - Pinto P
FIR - Cravo, A R
IR  - Cravo AR
FIR - Sequeira, G
IR  - Sequeira G
FIR - Santos, R A
IR  - Santos RA
FIR - Barcelos, A
IR  - Barcelos A
FIR - Cunha, I
IR  - Cunha I
FIR - Cruz, M
IR  - Cruz M
EDAT- 2014/02/07 06:00
MHDA- 2014/10/11 06:00
CRDT- 2014/02/07 06:00
PHST- 2013/07/06 00:00 [received]
PHST- 2013/09/11 00:00 [revised]
PHST- 2013/10/09 00:00 [accepted]
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - 10.1111/tan.12238 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Dec;82(6):374-9. doi: 10.1111/tan.12238.