PMID- 24498994
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20140206
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 6
DP  - 2013 Dec
TI  - Higher risk of uveitis and dactylitis and older age of onset among ankylosing 
      spondylitis patients with HLA-B*2705 than patients with HLA-B*2704 in the Chinese 
      population.
PG  - 380-6
LID - 10.1111/tan.12254 [doi]
AB  - Human leukocyte antigen (HLA)-B27 is closely associated with ankylosing 
      spondylitis (AS). However, the exact correlation between HLA-B27 subtypes and AS 
      manifestations remains unknown. This study aimed to investigate the correlation 
      between HLA-B27 polymorphism and the clinical features of AS. This study included 
      846 patients with AS and 959 healthy controls. Direct sequencing was used to 
      identify the HLA-B27 genotype. Clinical parameters, including age, age of onset, 
      family history, low back pain, peripheral arthritis, hip joint involvement, 
      dactylitis, uveitis, and sex ratio, were compared among patients with various 
      HLA-B27 subtypes. In total, 741 AS patients (87.6%) and 39 healthy controls (4%) 
      were HLA-B27-positive. The most prevalent subtypes were HLA-B*2704 (88%) and 
      HLA-B*2705 (10.1%) in patients with AS. Compared with HLA-B*2704-positive 
      patients, HLA-B*2705-positive patients demonstrated a significant increase in the 
      incidence of uveitis (16% vs 6.13%, P = 0.002) and dactylitis (9.3% vs 3.8%, 
      P = 0.028) and they had an older age of onset (22.9 +/- 8.0 vs 20.7 +/- 6.7 years, 
      P = 0.028). Binary logistic regression analysis revealed that presence of uveitis 
      was significantly associated with HLA-B*2705 (P = 0.008; odds ratio, 2.63; 95% 
      confidence interval, 1.283-5.393). There were no significant differences in 
      family history, low back pain, peripheral arthritis, or hip joint involvement 
      among HLA-B27 subtypes. Specific HLA-B27 subtypes were positively associated with 
      particular clinical features of AS. AS patients with HLA-B*2705 demonstrated an 
      older age of onset and had a higher risk of uveitis and dactylitis than did AS 
      patients with HLA-B*2704.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Qi, J
AU  - Qi J
AD  - Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Li, Q
AU  - Li Q
FAU - Lin, Z
AU  - Lin Z
FAU - Liao, Z
AU  - Liao Z
FAU - Wei, Q
AU  - Wei Q
FAU - Cao, S
AU  - Cao S
FAU - Rong, J
AU  - Rong J
FAU - Hu, Z
AU  - Hu Z
FAU - Yang, M
AU  - Yang M
FAU - Zhang, Y
AU  - Zhang Y
FAU - Lv, Q
AU  - Lv Q
FAU - Huang, J
AU  - Huang J
FAU - Pan, Y
AU  - Pan Y
FAU - Wu, Y
AU  - Wu Y
FAU - Jin, O
AU  - Jin O
FAU - Li, T
AU  - Li T
FAU - Gu, J
AU  - Gu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B*27:04 antigen)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - China
MH  - Disease Progression
MH  - Female
MH  - *Fingers
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Risk
MH  - Spondylitis, Ankylosing/*epidemiology/*genetics/immunology
MH  - *Toes
MH  - Uveitis/*genetics/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - HLA-B27
OT  - age of onset
OT  - ankylosing spondylitis
OT  - dactylitis
OT  - uveitis
EDAT- 2014/02/07 06:00
MHDA- 2014/10/11 06:00
CRDT- 2014/02/07 06:00
PHST- 2013/03/06 00:00 [received]
PHST- 2013/10/08 00:00 [revised]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - 10.1111/tan.12254 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Dec;82(6):380-6. doi: 10.1111/tan.12254.