PMID- 24498995
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20171116
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 6
DP  - 2013 Dec
TI  - IL-10 promoter polymorphisms influence susceptibility to aGvHD and are associated 
      with proportions of CD4+FoxP3+ lymphocytes in blood after hematopoietic stem cell 
      transplantation.
PG  - 387-96
LID - 10.1111/tan.12255 [doi]
AB  - Four hundred and ninety-five patients (390 and 105 grafted from unrelated and 
      sibling (SIB) donors, respectively) and their donors were analyzed for the impact 
      of interleukin-10 (IL-10) promoter genotype [rs18000896 (-1082 G/A), rs18000871 
      (-819 C/T) and rs18000872 (-592 C/A)] on the outcome of hematopoietic stem cell 
      transplantation (HSCT). Patients having ACC haplotype were at a lower risk of 
      acute graft versus host disease (aGvHD, grade > I) if transplanted from human 
      leukocyte antigen (HLA) well-matched (10/10) unrelated donors (20/135 vs 39/117, 
      P < 0.001, Pcorr = 0.002), which was not seen if patients were transplanted from 
      either sibling (SIB) or poorly matched (<10/10) unrelated donors (MUD). In 
      addition, GCC haplotype positive recipients of unrelated donor transplants tended 
      to be more susceptible to aGvHD (68/199 vs 39/169, P = 0.019, Pcorr = 0.057). 
      Multivariate logistic regression analysis in the MUD transplanted group showed 
      that donor-recipient human leukocyte antigen (HLA) mismatch [odds ratio 
      (OR) = 3.937, P = 0.001] and a lack of ACC haplotype in recipients (OR = 0.417, 
      P = 0.013) played a significant role as independent risk factors of aGvHD 
      grade > I. ACC carriers had higher proportions of FoxP3+ lymphocytes gated in 
      CD4+ lymphocytes as compared with patients with other IL-10 haplotypes. It was 
      seen at the time of hematological recovery (mean +/- SEM: 3.80 +/- 0.91% vs 
      2.06 +/- 0.98%, P = 0.012) and 2 weeks later (5.32 +/- 0.87% vs 2.50 +/- 0.83%, 
      P = 0.013); -592 C/A polymorphism was separately analyzed and it was found that 
      AA homozygotes tended to have a higher incidence of aGvHD (8/15 vs 116/456, 
      P = 0.034) and low proportions of FoxP3 CD4+ lymphocytes in blood (0.43 +/- 0.22% 
      vs 4.32 +/- 0.71%, P = 0.051) measured 2 weeks after hematological recovery. 
      Functional IL-10 polymorphism associated features influenced the risk of aGvHD 
      with a positive effect of ACC on the pool of Treg in blood.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Jaskula, E
AU  - Jaskula E
AD  - L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of 
      Sciences, Wroclaw, Poland.
FAU - Lange, A
AU  - Lange A
FAU - Dlubek, D
AU  - Dlubek D
FAU - Kyrcz-Krzemien, S
AU  - Kyrcz-Krzemien S
FAU - Markiewicz, M
AU  - Markiewicz M
FAU - Dzierzak-Mietla, M
AU  - Dzierzak-Mietla M
FAU - Jedrzejczak, W W
AU  - Jedrzejczak WW
FAU - Gronkowska, A
AU  - Gronkowska A
FAU - Nowak, J
AU  - Nowak J
FAU - Warzocha, K
AU  - Warzocha K
FAU - Hellmann, A
AU  - Hellmann A
FAU - Kowalczyk, J
AU  - Kowalczyk J
FAU - Drabko, K
AU  - Drabko K
FAU - Gozdzik, J
AU  - Gozdzik J
FAU - Mizia, S
AU  - Mizia S
CN  - Polish Donor-Recipient Matching Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (CD4 Antigens)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Acute Disease
MH  - CD4 Antigens/metabolism
MH  - Forkhead Transcription Factors/metabolism
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graft vs Host Disease/*genetics/immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Poland
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk
MH  - Siblings
MH  - T-Lymphocyte Subsets/*immunology
MH  - T-Lymphocytes, Regulatory/*immunology
OTO - NOTNLM
OT  - aGvHD
OT  - cytokine
OT  - hematopoietic stem cell transplantation
OT  - interleukin-10
OT  - promoter polymorphism
EDAT- 2014/02/07 06:00
MHDA- 2014/10/11 06:00
CRDT- 2014/02/07 06:00
PHST- 2013/06/21 00:00 [received]
PHST- 2013/09/13 00:00 [revised]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - 10.1111/tan.12255 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Dec;82(6):387-96. doi: 10.1111/tan.12255.