PMID- 24498996
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20140206
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 6
DP  - 2013 Dec
TI  - Influence of KIR genes and their HLA ligands in susceptibility to dengue in a 
      population from southern Brazil.
PG  - 397-404
LID - 10.1111/tan.12256 [doi]
AB  - Killer cell immunoglobulin-like receptors (KIR) form a group of regulatory 
      molecules that specifically recognise human leukocyte antigen (HLA) class I 
      molecules, modulating the cytolytic activity of natural killer cells. The purpose 
      of this study was to investigate the influence of KIR genes and their class I HLA 
      ligands in susceptibility to dengue fever in a population from southern Brazil 
      through a case-control study. One hundred four subjects with confirmed diagnoses 
      of dengue participated in this study, along with a control group of 172 
      individuals from the same geographic area. HLA and KIR genotyping was performed 
      by polymerase chain reaction with sequence-specific oligonucleotide probes 
      (PCR-SSOP) and with sequence-specific primer (PCR-SSP) techniques, respectively. 
      Data analysis showed significant differences for the KIR2DS1 (54.8% vs 40.7%, 
      P = 0.03), KIR2DS5 (50.0% vs 36.0%, P = 0.03) and KIR2DL5 (76.0% vs 56.4%, 
      P = 0.001) genes. With regard to KIR-ligand pairs, positive associations with 
      dengue were observed in KIR3DS1-Bw4 (45.2% vs 29.7%, P = 0.01), KIR3DL1-Bw4 
      (80.7% vs 65.1%, P < 0.001), KIR2DL1-C2 (75.0% vs 62.2%, P = 0.03) and KIR2DS1-C2 
      (40.4% vs 25.6%, P = 0.01) interactions, and a negative association in 
      KIR2DL3-C1/C1 (18.2% vs 33.1%, P = 0.01). Furthermore, the analysis of KIR 
      haplogroups showed a possible protective factor against dengue fever in 
      individuals with the AA genotype. Taken together, these results suggest the 
      existence of genetic predisposition to dengue fever in the population from 
      southern Brazil.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Beltrame, L M
AU  - Beltrame LM
AD  - Departamento de Ciencias Basicas da Saude, Universidade Estadual de Maringa, 
      Laboratorio de Imunogenetica, Av. Colombo 5790, Zona 07, CEP 87020-900, Maringa, 
      PR, Brazil.
FAU - Sell, A M
AU  - Sell AM
FAU - Moliterno, R A
AU  - Moliterno RA
FAU - Clementino, S L
AU  - Clementino SL
FAU - Cardozo, D M
AU  - Cardozo DM
FAU - Dalalio, M M
AU  - Dalalio MM
FAU - Fonzar, U J
AU  - Fonzar UJ
FAU - Visentainer, J E
AU  - Visentainer JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brazil
MH  - Case-Control Studies
MH  - Dengue/genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Protein Binding
MH  - Receptors, KIR/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - KIR genes
OT  - dengue
OT  - genetic polymorphisms
OT  - human leukocyte antigen
EDAT- 2014/02/07 06:00
MHDA- 2014/10/11 06:00
CRDT- 2014/02/07 06:00
PHST- 2013/01/16 00:00 [received]
PHST- 2013/09/05 00:00 [revised]
PHST- 2013/10/22 00:00 [accepted]
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - 10.1111/tan.12256 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Dec;82(6):397-404. doi: 10.1111/tan.12256.