PMID- 24500540
OWN - NLM
STAT- MEDLINE
DCOM- 20150221
LR  - 20220317
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 46
IP  - 8
DP  - 2014 Aug
TI  - Skeletal response to resistance and impact training in prostate cancer survivors.
PG  - 1482-8
LID - 10.1249/MSS.0000000000000265 [doi]
AB  - INTRODUCTION: Androgen deprivation therapy (ADT) is associated with significant 
      bone loss and an increase in fracture risk among prostate cancer survivors (PCS). 
      We investigated whether impact + resistance training could stop ADT-related 
      declines in bone mineral density (BMD) among PCS on ADT. METHODS: We randomized 
      51 PCS (mean age, 70.2 yr) currently prescribed ADT to participate in 1 yr of 
      impact + resistance training (Prevent Osteoporosis with Impact + Resistance 
      (POWIR)) or in an exercise placebo program of stretching exercise (FLEX). 
      Outcomes were proximal femur (total hip, femoral neck, and greater trochanter) 
      and spine (L1-L4) BMD (g.cm) and bone turnover markers (serum osteocalcin (ng.mL) 
      and urinary deoxypyrodinoline cross-links (nmol.mmol Cr)). RESULTS: Retention in 
      the 1-yr study was 84% and median attendance to supervised classes was 84% in 
      POWIR and 74% in FLEX. No study-related injuries were reported. There were no 
      significant differences between groups for average L1-L4 BMD or for BMD at any 
      hip site. When examining individual vertebrae, POWIR has a significant effect on 
      preservation of BMD (-0.4%) at the L4 vertebrae compared with losses (-3.1%) in 
      FLEX (P = 0.03). CONCLUSION: Impact + resistance training was a safe and 
      acceptable form of exercise for older PCS on ADT. Among our limited sample, POWIR 
      did not appear to have a clinically meaningful effect on hip or spine BMD, but 
      some evidence of skeletal adaptation to resistance + impact training in an 
      androgen-deprived state was apparent. Future studies need to be conducted on a 
      larger sample of patients and should consider modifications to POWIR that could 
      further enhance loading across the spine and at the hip to preserve BMD at these 
      clinically relevant sites.
FAU - Winters-Stone, Kerri M
AU  - Winters-Stone KM
AD  - 1School of Nursing, Oregon Health and Science University, Portland, OR; 2School 
      of Medicine, Oregon Health and Science University, Portland, OR; and 3Knight 
      Cancer Institute, Oregon Health and Science University, Portland, OR; 4Department 
      of Exercise and Sport Science, School of Biologic and Population Health, Oregon 
      State University, Corvallis, OR.
FAU - Dobek, Jessica C
AU  - Dobek JC
FAU - Bennett, Jill A
AU  - Bennett JA
FAU - Maddalozzo, Gianni F
AU  - Maddalozzo GF
FAU - Ryan, Christopher W
AU  - Ryan CW
FAU - Beer, Tomasz M
AU  - Beer TM
LA  - eng
GR  - P30 CA069533/CA/NCI NIH HHS/United States
GR  - R01 CA163474/CA/NCI NIH HHS/United States
GR  - R21 CA137272/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Androgen Antagonists)
SB  - IM
MH  - Androgen Antagonists/*therapeutic use
MH  - *Bone Density
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - Male
MH  - Osteoporosis/*prevention & control
MH  - Prostatic Neoplasms/*drug therapy/physiopathology
MH  - *Resistance Training
MH  - Single-Blind Method
MH  - Survivors
PMC - PMC4101037
MID - NIHMS561216
EDAT- 2014/02/07 06:00
MHDA- 2015/02/24 06:00
PMCR- 2015/08/01
CRDT- 2014/02/07 06:00
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 10.1249/MSS.0000000000000265 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2014 Aug;46(8):1482-8. doi: 10.1249/MSS.0000000000000265.