PMID- 24501380
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20220408
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 221
IP  - 1
DP  - 2014 Apr
TI  - High-fat diet aggravates glucose homeostasis disorder caused by chronic exposure 
      to bisphenol A.
PG  - 167-79
LID - 10.1530/JOE-13-0386 [doi]
AB  - Epidemiological findings on the association between bisphenol A (BPA, 
      2,2-bis-(4-hydroxyphenyl)propane) exposure and type 2 diabetes mellitus (T2DM) 
      are paradoxical. In animal studies, BPA has been shown to disrupt pancreatic 
      function and blood glucose homeostasis even at a reference 'safe' level during 
      perinatal period. In this study, we explored the effects of long-term paternal 
      exposure to a 'safe' level of BPA on parents themselves and their offspring. 
      Adult male genitor rats fed with either standard chow diet (STD) or high-fat diet 
      (HFD) were treated respectively with either vehicle or BPA (50 mug/kg per day) for 
      35 weeks. The male rats treated with vehicle or BPA for 21 weeks were then used 
      as sires, and the adult female rats were fed with STD during the gestation and 
      lactation. Offspring rats were weaned on postnatal day 21 and fed with STD in 
      later life. Metabolic parameters were recorded on the adult male rats and their 
      adult offspring. BPA exposure disrupted glucose homeostasis and pancreatic 
      function, and HFD aggravated these adverse effects. However, BPA exposure did not 
      alter body weight, body fat percentage, or serum lipid. In addition, the paternal 
      BPA exposure did not cause adverse reproductive consequence or metabolic disorder 
      in the adult offspring. Our findings indicate that chronic exposure to a 
      predicted 'safe' dose of BPA contributes to glucose metabolic disorders, and that 
      HFD aggravates these adverse effects in paternal rats.
FAU - Ding, Shibin
AU  - Ding S
AD  - Department of Nutrition and Food Hygiene MOE Key Lab of Environment and Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, 13 Hangkong Road, Wuhan 430030, People's Republic of China School 
      of Environmental Science and Public Health, Wenzhou Medical College, Wenzhou 
      325000, China.
FAU - Fan, Ying
AU  - Fan Y
FAU - Zhao, Nana
AU  - Zhao N
FAU - Yang, Huiqin
AU  - Yang H
FAU - Ye, Xiaolei
AU  - Ye X
FAU - He, Dongliang
AU  - He D
FAU - Jin, Xin
AU  - Jin X
FAU - Liu, Jian
AU  - Liu J
FAU - Tian, Chong
AU  - Tian C
FAU - Li, Hongyu
AU  - Li H
FAU - Xu, Shunqing
AU  - Xu S
FAU - Ying, Chenjiang
AU  - Ying C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140317
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phenols)
RN  - IY9XDZ35W2 (Glucose)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/*adverse effects
MH  - Body Weight/drug effects
MH  - Diet, High-Fat/*adverse effects
MH  - Endocrine Disruptors/adverse effects
MH  - Female
MH  - Glucose/*metabolism
MH  - Homeostasis/*drug effects
MH  - Humans
MH  - Male
MH  - Metabolic Diseases/etiology/*metabolism/physiopathology
MH  - Pedigree
MH  - Phenols/*adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/etiology/*metabolism/physiopathology
MH  - Rats
OTO - NOTNLM
OT  - autophagy
OT  - bisphenol A
OT  - endocrine disruptor
OT  - glucose homeostasis
OT  - high-fat diet
EDAT- 2014/02/07 06:00
MHDA- 2014/05/13 06:00
CRDT- 2014/02/07 06:00
PHST- 2014/02/07 06:00 [entrez]
PHST- 2014/02/07 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
AID - JOE-13-0386 [pii]
AID - 10.1530/JOE-13-0386 [doi]
PST - epublish
SO  - J Endocrinol. 2014 Mar 17;221(1):167-79. doi: 10.1530/JOE-13-0386. Print 2014 
      Apr.