PMID- 24502840
OWN - NLM
STAT- MEDLINE
DCOM- 20140610
LR  - 20191210
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 95
IP  - 5
DP  - 2014 May
TI  - Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis 
      grouped according to Medical Research Council dyspnea grade.
PG  - 950-5
LID - S0003-9993(14)00071-9 [pii]
LID - 10.1016/j.apmr.2014.01.016 [doi]
AB  - OBJECTIVE: To investigate the relations between Medical Research Council (MRC) 
      dyspnea grade and peripheral muscle force, activities of daily living (ADL) 
      performance, health status, lung function, and exercise capacity in subjects with 
      idiopathic pulmonary fibrosis (IPF). DESIGN: Prospective cross-sectional 
      observational study. SETTING: University hospital. PARTICIPANTS: Subjects with 
      IPF (N=65, 46 men) in a stable clinical state with a mean age of 68+/-7 years. 
      INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Right ventricular systolic 
      pressure (RVSP) via transthoracic echocardiography, pulmonary function, isometric 
      quadriceps force (QF) and handgrip force (HF), 6-minute walk distance (6MWD), ADL 
      score, and health status (Medical Outcomes Study 36-Item Short-Form Health Survey 
      [SF-36]) were assessed and compared between subjects grouped according to MRC 
      grade. RESULTS: Of the participants, 16 were in MRC grade 2, 17 were in MRC grade 
      3, 17 were in MRC grade 4, and 15 were in MRC grade 5. RVSP, pulmonary function, 
      QF, HF, 6MWD, ADL, and SF-36 scores decreased with increasing MRC grade (all 
      P<.001). All measures were lower (P<.05) in subjects with grades 4 and 5 than 
      subjects with grades 2 and 3. Strong associations were found between MRC grade 
      and 6MWD (rho=-.89, P=.001) and ADL score (rho=-.82, P=.001). MRC grade was also 
      associated with RVSP, pulmonary function, QF, and HF (all rho>/=.56, P=.001). 
      CONCLUSIONS: The MRC dyspnea scale provides a simple and useful method of 
      categorizing individuals with IPF with respect to their activity limitation and 
      may assist in understanding the impact of IPF on an individual.
CI  - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Kozu, Ryo
AU  - Kozu R
AD  - Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, 
      Japan; Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA, 
      Australia; School of Physiotherapy and Exercise Science, Curtin University, 
      Perth, WA, Australia. Electronic address: ryokozu@nagasaki-u.ac.jp.
FAU - Jenkins, Sue
AU  - Jenkins S
AD  - Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA, Australia; 
      School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, 
      Australia; Lung Institute of Western Australia and Centre for Asthma, Allergy and 
      Respiratory Research, University of Western Australia, Perth, WA, Australia.
FAU - Senjyu, Hideaki
AU  - Senjyu H
AD  - Department of Cardiopulmonary Rehabilitation Science, Graduate School of 
      Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140203
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged
MH  - Dyspnea/etiology/physiopathology/rehabilitation
MH  - Exercise Therapy/*methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Forced Expiratory Volume
MH  - Hand Strength/*physiology
MH  - Health Status
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/complications/physiopathology/*rehabilitation
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Prospective Studies
OTO - NOTNLM
OT  - Dyspnea
OT  - Idiopathic pulmonary fibrosis
OT  - Rehabilitation
EDAT- 2014/02/08 06:00
MHDA- 2014/06/11 06:00
CRDT- 2014/02/08 06:00
PHST- 2013/12/21 00:00 [received]
PHST- 2014/01/16 00:00 [revised]
PHST- 2014/01/17 00:00 [accepted]
PHST- 2014/02/08 06:00 [entrez]
PHST- 2014/02/08 06:00 [pubmed]
PHST- 2014/06/11 06:00 [medline]
AID - S0003-9993(14)00071-9 [pii]
AID - 10.1016/j.apmr.2014.01.016 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2014 May;95(5):950-5. doi: 10.1016/j.apmr.2014.01.016. 
      Epub 2014 Feb 3.