PMID- 24503118
OWN - NLM
STAT- MEDLINE
DCOM- 20141105
LR  - 20220410
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 264
DP  - 2014 May 1
TI  - Resveratrol reverses the effects of chronic unpredictable mild stress on 
      behavior, serum corticosterone levels and BDNF expression in rats.
PG  - 9-16
LID - S0166-4328(14)00053-9 [pii]
LID - 10.1016/j.bbr.2014.01.039 [doi]
AB  - Depression is one of the most common neuropsychiatric disorders and has been 
      associated with the neuroendocrine system and alterations in specific brain 
      proteins. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum 
      and has diverse biological activities, including potent antidepressant-like 
      effects. The present study attempts to explore the mechanisms underlying the 
      antidepressant-like action of resveratrol by measuring serum corticosterone 
      levels and the content of brain derived neurotrophic factor (BDNF) in the 
      hippocampus and amygdala of rats exposed to the chronic unpredictable mild stress 
      (CUMS). Male Wistar rats were subjected to the CUMS protocol for a period of 5 
      weeks to induce depressive-like behavior. Resveratrol treatment (20, 40 and 
      80mg/kg/i.p. 5 weeks) significantly reversed the CUMS-induced behavioral 
      abnormalities (reduced sucrose preference, increased immobility time and 
      decreased locomotor activity) and the elevated serum corticosterone levels 
      observed in stressed rats. Additionally, 5-weeks of CUMS exposure significantly 
      decreased BDNF levels in the hippocampus and amygdala, and was accompanied by 
      decreased phosphorylation of extracellular signal-regulated kinase (pERK) and 
      cAMP response element-binding protein (pCREB), while resveratrol treatment 
      normalized these levels. All of these effects of resveratrol were essentially 
      identical to that observed with the established antidepressant, desipramine. In 
      conclusion, our study shows that resveratrol exerted antidepressant-like effects 
      in CUMS rats, mediated in part by normalizing serum corticosterone levels while 
      up-regulating pERK, pCREB and BDNF levels in the hippocampus and amygdala.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Liu, Dexiang
AU  - Liu D
AD  - Department of Medical Psychology, Shandong University School of Medicine, 44 no., 
      Wenhua Xi Road, Jinan, Shandong 250012, PR China.
FAU - Xie, Kai
AU  - Xie K
AD  - Department of Medical Psychology, Shandong University School of Medicine, 44 no., 
      Wenhua Xi Road, Jinan, Shandong 250012, PR China.
FAU - Yang, Xudong
AU  - Yang X
AD  - Department of Physiology, Shandong University School of Medicine, 44 no., Wenhua 
      Xi Road, Jinan, Shandong 250012, PR China.
FAU - Gu, Jianhua
AU  - Gu J
AD  - Department of Physiology, Shandong University School of Medicine, 44 no., Wenhua 
      Xi Road, Jinan, Shandong 250012, PR China.
FAU - Ge, Li
AU  - Ge L
AD  - Department of Histology and Embryology of Taishan Medical University, Taian, 
      Shandong 271000, PR China.
FAU - Wang, Xueer
AU  - Wang X
AD  - Institute of Bioscience, Luoyang Normal University, 71 no., Longmen Road, 
      Luoyang, Henan 471022, PR China; Department of Medical Psychology, Shandong 
      University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR 
      China.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Physiology, Shandong University School of Medicine, 44 no., Wenhua 
      Xi Road, Jinan, Shandong 250012, PR China. Electronic address: 
      wangzhen@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140204
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Stilbenes)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - Q369O8926L (Resveratrol)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - CREB-Binding Protein/blood
MH  - Corticosterone/*blood
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Exploratory Behavior/drug effects
MH  - Food Deprivation
MH  - Food Preferences/drug effects
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Resveratrol
MH  - Stilbenes/*therapeutic use
MH  - *Stress, Psychological/blood/drug therapy/physiopathology
MH  - Swimming/psychology
MH  - Time Factors
OTO - NOTNLM
OT  - Chronic unpredictable mild stress (CUMS)
OT  - Resveratrol
OT  - brain derived neurotrophic factor (BDNF)
OT  - hypothalamic-pituitary-adrenal (HPA)
EDAT- 2014/02/08 06:00
MHDA- 2014/11/06 06:00
CRDT- 2014/02/08 06:00
PHST- 2013/09/22 00:00 [received]
PHST- 2014/01/02 00:00 [revised]
PHST- 2014/01/28 00:00 [accepted]
PHST- 2014/02/08 06:00 [entrez]
PHST- 2014/02/08 06:00 [pubmed]
PHST- 2014/11/06 06:00 [medline]
AID - S0166-4328(14)00053-9 [pii]
AID - 10.1016/j.bbr.2014.01.039 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 May 1;264:9-16. doi: 10.1016/j.bbr.2014.01.039. Epub 2014 
      Feb 4.