PMID- 24503120
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 263
DP  - 2014 Apr 15
TI  - Hippocampal BDNF treatment facilitates consolidation of spatial memory in 
      spontaneous place recognition in rats.
PG  - 210-6
LID - S0166-4328(14)00048-5 [pii]
LID - 10.1016/j.bbr.2014.01.034 [doi]
AB  - In order to investigate the role of brain-derived neurotrophic factor (BDNF) in 
      the consolidation of spatial memory, we examined the relationship between the 
      increase of hippocampal BDNF and the establishment of long-term spatial memory in 
      spontaneous place recognition test in rats. The test consisted of a sample phase, 
      delay interval, and a test phase, and preferred exploration of the object in a 
      novel place compared with that in a familiar place was assessed in the test 
      phase. In experiment 1, dorsal hippocampal administration of anisomycin, a 
      protein synthesis inhibitor, before the sample phase (20 min) abolished the 
      preference for the novel place object in the test phase conducted 24h later. This 
      impairment was reversed by the dorsal hippocampal BDNF treatment immediately 
      after the sample phase, although the BDNF treatment alone did not improve 
      performance. In experiment 2, we used a shorter sample phase condition (5 min) in 
      which control rats did not show any preference for the novel place object in the 
      test phase after 24h delay, and found that BDNF treatment immediately after the 
      sample phase caused rats' significant preference for it. Results suggest an 
      important role of hippocampal BDNF as a product of protein synthesis that is 
      required for the consolidation of spatial memory.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Ozawa, Takaaki
AU  - Ozawa T
AD  - Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, 
      Tsukuba 305-8577, Ibaraki, Japan; Laboratory for Neural Circuitry of Memory, 
      RIKEN Brain Science Institute, Hirosawa, Wako 351-0198, Saitama, Japan.
FAU - Yamada, Kazuo
AU  - Yamada K
AD  - Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, 
      Tsukuba 305-8577, Ibaraki, Japan.
FAU - Ichitani, Yukio
AU  - Ichitani Y
AD  - Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, 
      Tsukuba 305-8577, Ibaraki, Japan. Electronic address: 
      y-ichit@human.tsukuba.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140203
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 6C74YM2NGI (Anisomycin)
SB  - IM
MH  - Animals
MH  - Anisomycin/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Exploratory Behavior/drug effects/physiology
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - Memory/drug effects/*physiology
MH  - Neuropsychological Tests
MH  - Protein Synthesis Inhibitors/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Recognition, Psychology/drug effects/*physiology
MH  - Space Perception/drug effects/*physiology
MH  - Task Performance and Analysis
MH  - Time Factors
OTO - NOTNLM
OT  - BDNF
OT  - Consolidation
OT  - Hippocampus
OT  - Rats
OT  - Spatial memory
OT  - Spontaneous place recognition
EDAT- 2014/02/08 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/08 06:00
PHST- 2013/02/16 00:00 [received]
PHST- 2014/01/22 00:00 [revised]
PHST- 2014/01/24 00:00 [accepted]
PHST- 2014/02/08 06:00 [entrez]
PHST- 2014/02/08 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0166-4328(14)00048-5 [pii]
AID - 10.1016/j.bbr.2014.01.034 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Apr 15;263:210-6. doi: 10.1016/j.bbr.2014.01.034. Epub 2014 
      Feb 3.