PMID- 24503406
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20140421
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 157
IP  - 5
DP  - 2014 May
TI  - Pseudodrusen subtypes as delineated by multimodal imaging of the fundus.
PG  - 1005-12
LID - S0002-9394(14)00055-5 [pii]
LID - 10.1016/j.ajo.2014.01.025 [doi]
AB  - PURPOSE: To subclassify pseudodrusen based on their appearance in multimodal 
      imaging. DESIGN: Retrospective, observational series. METHODS: The color fundus 
      photographs and infrared scanning laser ophthalmoscope (IR-SLO) images of 
      patients with pseudodrusen were evaluated along with spectral-domain optical 
      coherence tomography (SD OCT) by masked readers. Distinct types of pseudodrusen 
      could be differentiated. RESULTS: There were 140 eyes of 93 patients with a mean 
      age of 82.4 years. Multimodal imaging analysis showed 3 subtypes of pseudodrusen. 
      One principal type was an orderly array of whitish discrete accumulations 
      principally located in the perifovea, termed dot pseudodrusen. They appeared as 
      hyporeflective spots, often with a target configuration, in IR-SLO images. The 
      second type was interconnected bands of yellowish-white material forming a 
      reticular pattern, called ribbon pseudodrusen, which were located in the 
      perifovea. This subtype was faintly hyporeflective in IR-SLO imaging. Dot 
      pseudodrusen were detected more commonly with IR-SLO imaging than in color 
      photography (P = .014) and ribbon pseudodrusen were seen more frequently in color 
      than in IR-SLO images (P < .001). An uncommon third type of pseudodrusen, 
      yellow-white globules primarily located peripheral to the perifoveal region, 
      appeared hyper-reflective in IR-SLO and were called peripheral pseudodrusen. All 
      3 types were seen as subretinal drusenoid deposits by SD OCT. CONCLUSION: 
      Pseudodrusen may be classified into at least 3 categories, each with optimal 
      methods of detection and only 1 that formed a reticular pattern. These findings 
      suggest pseudodrusen could contain differing constituents and therefore may vary 
      in conferred risk for progression to advanced age-related macular disease.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Suzuki, Mihoko
AU  - Suzuki M
AD  - Vitreous Retina Macula Consultants of New York; and the LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.
FAU - Sato, Taku
AU  - Sato T
AD  - Vitreous Retina Macula Consultants of New York; and the LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.
FAU - Spaide, Richard F
AU  - Spaide RF
AD  - Vitreous Retina Macula Consultants of New York; and the LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York. 
      Electronic address: rick.spaide@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140203
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Multimodal Imaging/*methods
MH  - Ophthalmoscopy
MH  - Photography
MH  - Retinal Drusen/*classification/diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
EDAT- 2014/02/08 06:00
MHDA- 2014/06/21 06:00
CRDT- 2014/02/08 06:00
PHST- 2013/10/31 00:00 [received]
PHST- 2014/01/27 00:00 [revised]
PHST- 2014/01/29 00:00 [accepted]
PHST- 2014/02/08 06:00 [entrez]
PHST- 2014/02/08 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - S0002-9394(14)00055-5 [pii]
AID - 10.1016/j.ajo.2014.01.025 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 May;157(5):1005-12. doi: 10.1016/j.ajo.2014.01.025. Epub 
      2014 Feb 3.