PMID- 24504124
OWN - NLM
STAT- MEDLINE
DCOM- 20141126
LR  - 20211021
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 44
IP  - 4
DP  - 2014 Apr
TI  - The roles of transforming growth factor-beta, Wnt, Notch and hypoxia on liver 
      progenitor cells in primary liver tumours (Review).
PG  - 1015-22
LID - 10.3892/ijo.2014.2286 [doi]
AB  - Primary liver tumours have a high incidence and mortality. The most important 
      forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can 
      occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver 
      progenitor cells (LPCs) are bipotential stem cells activated in case of severe 
      liver damage and are capable of forming both cholangiocytes and hepatocytes. 
      Possibly, alterations in Wnt, transforming growth factor-beta, Notch and hypoxia 
      pathways in these LPCs can cause them to give rise to cancer stem cells, capable 
      of driving tumourigenesis. In this review, we summarize and discuss current 
      knowledge on the role of these pathways in LPC activation and differentiation 
      during hepatocarcinogenesis.
FAU - Bogaerts, Eliene
AU  - Bogaerts E
AD  - Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 
      9000 Gent, Belgium.
FAU - Heindryckx, Femke
AU  - Heindryckx F
AD  - Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 
      Uppsala, Sweden.
FAU - Vandewynckel, Yves-Paul
AU  - Vandewynckel YP
AD  - Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 
      9000 Gent, Belgium.
FAU - Van Grunsven, Leo A
AU  - Van Grunsven LA
AD  - Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, 
      1090 Brussels, Belgium.
FAU - Van Vlierberghe, Hans
AU  - Van Vlierberghe H
AD  - Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 
      9000 Gent, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140203
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Receptors, Notch)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Bile Duct Neoplasms/pathology
MH  - Bile Ducts, Intrahepatic/pathology
MH  - Carcinoma, Hepatocellular/pathology
MH  - Cell Differentiation
MH  - Cell Hypoxia/*physiology
MH  - Cell Transformation, Neoplastic
MH  - Cholangiocarcinoma/pathology
MH  - Humans
MH  - Liver/pathology
MH  - Liver Neoplasms/pathology
MH  - Receptors, Notch/*metabolism
MH  - Stem Cells/cytology/*pathology
MH  - Transforming Growth Factor beta/*metabolism
MH  - Wnt Proteins/*metabolism
MH  - Wnt Signaling Pathway
PMC - PMC3977811
EDAT- 2014/02/08 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/02/03
CRDT- 2014/02/08 06:00
PHST- 2013/10/25 00:00 [received]
PHST- 2013/11/28 00:00 [accepted]
PHST- 2014/02/08 06:00 [entrez]
PHST- 2014/02/08 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/02/03 00:00 [pmc-release]
AID - ijo-44-04-1015 [pii]
AID - 10.3892/ijo.2014.2286 [doi]
PST - ppublish
SO  - Int J Oncol. 2014 Apr;44(4):1015-22. doi: 10.3892/ijo.2014.2286. Epub 2014 Feb 3.