PMID- 24505514
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140207
LR  - 20211021
IS  - 2008-3009 (Print)
IS  - 2008-2207 (Electronic)
IS  - 2008-2207 (Linking)
VI  - 7
IP  - 1
DP  - 2013
TI  - Expansion of CD133(+) Umbilical Cord Blood Derived Hematopoietic Stem Cells on a 
      Biocompatible Microwells.
PG  - 9-14
AB  - Umbilical cord Blood (UCB) as a source of Hematopoietic Stem/Progenitor cells 
      (HSPCs) used for Umbilical cord blood transplantation (UCBT). The main obstacle 
      in application of this source as an appropriate source of HSPCs is low volume of 
      this product. So ex vivo expansion of these cells in a microenvironment which 
      mimic body condition is important. In current study we designed biocompatible 
      microwells in which collagene type I is coated by softlitography method. Our 
      findings designated that in 3-Dimensional (3D) microenvironment CD133(+) UCB 
      derived HSC expanded significantly compared to 2-Dimensional (2D) 
      microenvironment.
FAU - Soufizomorrod, Mina
AU  - Soufizomorrod M
AD  - Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, 
      Iran.
FAU - Soleimani, Masoud
AU  - Soleimani M
AD  - Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, 
      Iran.
FAU - Hajifathali, Abbas
AU  - Hajifathali A
AD  - Department of Medical Oncology and Hematology, Taleghani Hospital, Shahid 
      Beheshti University (MC), Tehran, Iran.
FAU - Mohammadi, Majid Mossahebi
AU  - Mohammadi MM
AD  - Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, 
      Iran.
FAU - Abroun, Saeed
AU  - Abroun S
AD  - Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Hematol Oncol Stem Cell Res
JT  - International journal of hematology-oncology and stem cell research
JID - 101511150
PMC - PMC3913131
OTO - NOTNLM
OT  - Biocompatible microwells
OT  - CD133+ umbilical cord blood derived
EDAT- 2014/02/08 06:00
MHDA- 2014/02/08 06:01
PMCR- 2013/01/01
CRDT- 2014/02/08 06:00
PHST- 2012/10/24 00:00 [received]
PHST- 2012/12/01 00:00 [accepted]
PHST- 2014/02/08 06:00 [entrez]
PHST- 2014/02/08 06:00 [pubmed]
PHST- 2014/02/08 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - IJHOSCR-7-009 [pii]
PST - ppublish
SO  - Int J Hematol Oncol Stem Cell Res. 2013;7(1):9-14.