PMID- 24505896
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20151119
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 117
IP  - 1
DP  - 2013 Jan-Mar
TI  - Aspects of the molecular-genetic profile in patients with ischemic heart disease.
PG  - 78-82
AB  - AIM: To assess the clinical and molecular-genetic aspects in patients with 
      various forms of ischemic heart disease (IHD). MATERIAL AND METHODS: This 
      case-control study was conducted in the interval 2007-2011 and included 405 
      patients with acute coronary episodes admitted to the Chisinau "Sfanta Treime" 
      Municipal Hospital and Institute of Cardiology. Polymorphism of candidate genes 
      angiotensin converting enzyme (ACE), angiotensin II type 1 receptors (AT1R), 
      endothelial nitric oxide synthase (eNOS), and platelet GPIIb/IIIa receptors 
      (PlA1/PlA2) were identified by amplified fragment length (AFLP) and restriction 
      fragment length polymorphism (RFLP). RESULTS: There were significant differences 
      in the frequency of D risk alleles in coronary patients compared with controls 
      (78.65% vs. 61.24%, p < 0.05). The distribution of angiotensin II type 1 receptor 
      A1166C gene polymorphism in the group of patients with IHD was: AA genotype--72 
      (25.74%), CC genotype--47 (16.78%), CA genotype--161 (59.28%) patients. 
      CONCLUSIONS: GPIIb/IIIa A2A2 gene haplotype is associated with susceptibility to 
      IHD and increased prevalence of dyslipidemia, particularly in smokers. The 
      carrier state of DD genotype and D allele of ACE gene can be used as markers of 
      increased risk for IHD and myocardial infarction (MI) and is associated with 
      increased blood pressure.
FAU - Capros, Natalia
AU  - Capros N
AD  - Institute of Genetics and Plant Physiology, Academy of Science, Chisinau, 
      Republic of Moldova.
FAU - Barbacar, N
AU  - Barbacar N
AD  - Faculty of Medicine, Nicolae Testemitanu State University of Medicine and 
      Pharmacy, Chisinau.
FAU - Istrati, V
AU  - Istrati V
AD  - Institute of Genetics and Plant Physiology, Academy of Science, Chisinau, 
      Republic of Moldova.
FAU - Braniste, T
AU  - Braniste T
AD  - Institute of Genetics and Plant Physiology, Academy of Science, Chisinau, 
      Republic of Moldova.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (Biomarkers)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Amplified Fragment Length Polymorphism Analysis
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Coronary Artery Disease/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*genetics
MH  - Nitric Oxide Synthase Type III/*genetics
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/*genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Receptor, Angiotensin, Type 1/*genetics
EDAT- 2014/02/11 06:00
MHDA- 2014/03/25 06:00
CRDT- 2014/02/11 06:00
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2013 Jan-Mar;117(1):78-82.