PMID- 24507024
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20140210
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 46
IP  - 1
DP  - 2014 Jan-Feb
TI  - Effect of donor body mass index on the outcome of donation after cardiac death 
      kidneys: how big is too big?
PG  - 46-9
LID - S0041-1345(13)01086-5 [pii]
LID - 10.1016/j.transproceed.2013.07.068 [doi]
AB  - INTRODUCTION: Morbid obesity (MO) has become an epidemic in the United Sates and 
      is associated with adverse effects on health. The purpose of this study was to 
      examine the effects of MO on the short-term outcomes of kidneys transplanted from 
      donation after cardiac death (DCD) donors. PATIENTS AND METHODS: Using a 
      prospectively collected database, we reviewed 467 kidney transplantations 
      performed at a single center between January 2008 and June 2011 to identify 67 
      recipients who received transplants from 40 DCD donors. The outcomes of 14 MO DCD 
      donor kidneys were compared with 53 non-MO DCD grafts. MO was defined as a body 
      mass index >/= 35. Mean patient follow-up was 16 months. RESULTS: The MO and non-MO 
      DCD donor groups were similar with respect to donor and recipient age, gender, 
      race, cause of death and renal disease, time from withdrawal of life support to 
      organ perfusion, mean human leukocyte antigen (HLA) mismatch, and overall 
      recipient survival. Organs from MO DCD donors also had comparable rates of 
      delayed graft function (21.4% vs 20.0%; P = not significant [NS]). At 1 year 
      post-transplantation, a small but statistically insignificant difference was 
      observed in the graft survival rates of MO and non-MO donors (87% vs. 96%; P = 
      NS). One MO kidney had primary nonfunction. CONCLUSIONS: These data demonstrate 
      that kidneys procured from MO DCD donors have equivalent short-term outcomes 
      compared with non-MO grafts and should continue to be used. Further investigation 
      is needed to examine the effect of MO on long-term renal allograft survival.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Jin, L X
AU  - Jin LX
AD  - Washington University School of Medicine, St. Louis, Missouri, USA.
FAU - Pitt, S C
AU  - Pitt SC
AD  - Department of Surgery, Section of Transplant Surgery, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Doyle, M B
AU  - Doyle MB
AD  - Department of Surgery, Section of Transplant Surgery, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Klein, C
AU  - Klein C
AD  - Department of Medicine, Division of Nephrology, Washington University School of 
      Medicine, St. Louis, Missouri, USA.
FAU - Shenoy, S
AU  - Shenoy S
AD  - Department of Surgery, Section of Transplant Surgery, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Lowell, J A
AU  - Lowell JA
AD  - Department of Surgery, Section of Transplant Surgery, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Chapman, W C
AU  - Chapman WC
AD  - Department of Surgery, Section of Transplant Surgery, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Wellen, J R
AU  - Wellen JR
AD  - Department of Surgery, Section of Transplant Surgery, Washington University 
      School of Medicine, St. Louis, Missouri, USA. Electronic address: 
      wellenj@wudosis.wustl.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - *Body Mass Index
MH  - Databases, Factual
MH  - *Death
MH  - Delayed Graft Function/etiology
MH  - Female
MH  - Graft Survival
MH  - Humans
MH  - Kidney/*pathology
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement/*methods
MH  - Treatment Outcome
EDAT- 2014/02/11 06:00
MHDA- 2015/01/16 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/06/28 00:00 [received]
PHST- 2013/07/24 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - S0041-1345(13)01086-5 [pii]
AID - 10.1016/j.transproceed.2013.07.068 [doi]
PST - ppublish
SO  - Transplant Proc. 2014 Jan-Feb;46(1):46-9. doi: 
      10.1016/j.transproceed.2013.07.068.