PMID- 24507672
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20181202
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 7
IP  - 4
DP  - 2014 Apr
TI  - Experimental treatment of radiation pneumonitis with human umbilical cord 
      mesenchymal stem cells.
PG  - 262-6
LID - S1995-7645(14)60034-1 [pii]
LID - 10.1016/S1995-7645(14)60034-1 [doi]
AB  - OBJECTIVE: To evaluate of the curative effect of human umbilical cord mesenchymal 
      stem cells (hUC-MSCs) on rat acute radiation pneumonitis. METHODS: Fourty rats 
      were randomly divided into control group, radiation group, stem cell prevention 
      group, stem cell treatment group and prednisone treatment group. All rats except 
      those in the control group were radiated with X ray to establish the acute 
      radiation pneumonitis damage model. The hUC-MSCs cultured in vitro was 
      administrated to the rats of the prevention group via tail vein (1x10(6) cells/kg 
      BW) 24 h before the radiation, while the same administration was performed in the 
      rats of the treatment group 24 h after the radiation. After 24 h post the 
      radiation, the rats in the radiation group were given 0.4 mL physiological 
      saline, and those in the prednisone group were given 1 mg/kg prednisone. All rats 
      were observed and executed 72 h after the radiation to detect lung histological 
      changes. RESULTS: After the administration of hUC-MSCs, the survival status of 
      the rats in the prevention group and treatment group was obviously better than 
      that in the control group. As shown by the histological staining, the morphology, 
      proliferation activity and bronchial state of lung tissues were better in the 
      prevention group and treatment group than in the control group. CONCLUSIONS: The 
      hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in 
      rats.
CI  - Copyright (c) 2014 Hainan Medical College. Published by Elsevier B.V. All rights 
      reserved.
FAU - Wang, Rui
AU  - Wang R
AD  - Department of Spinal Cord Repairing, Jinan Military General Hospital, Jinan 
      250031, China.
FAU - Zhu, Chang-zheng
AU  - Zhu CZ
AD  - Department of Neurology, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
FAU - Qiao, Ping
AU  - Qiao P
AD  - Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
FAU - Liu, Jian
AU  - Liu J
AD  - Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
FAU - Zhao, Qiang
AU  - Zhao Q
AD  - Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
FAU - Wang, Kui-jie
AU  - Wang KJ
AD  - Department of Neurology, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
FAU - Zhao, Ting-bao
AU  - Zhao TB
AD  - Department of Spinal Cord Repairing, Jinan Military General Hospital, Jinan 
      250031, China. Electronic address: woaifei371328@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Lung/pathology
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/*cytology
MH  - Radiation Pneumonitis/pathology/*surgery
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Human umbilical cord mesenchymal stem cell
OT  - Radiation pneumonitis
OT  - Rat
EDAT- 2014/02/11 06:00
MHDA- 2014/10/01 06:00
CRDT- 2014/02/11 06:00
PHST- 2014/01/10 00:00 [received]
PHST- 2014/02/15 00:00 [revised]
PHST- 2014/03/15 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S1995-7645(14)60034-1 [pii]
AID - 10.1016/S1995-7645(14)60034-1 [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2014 Apr;7(4):262-6. doi: 10.1016/S1995-7645(14)60034-1.