PMID- 24507684
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20180219
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 7
IP  - 4
DP  - 2014 Apr
TI  - Effect of RSCs combined with COP-1 on optic nerve damage in glaucoma rat model.
PG  - 317-20
LID - S1995-7645(14)60047-X [pii]
LID - 10.1016/S1995-7645(14)60047-X [doi]
AB  - OBJECTIVE: To explore effect of retinal stem cells (RSCs) combined with 
      copolymer-1 (COP-1) immunotherapy on optic nerve damage in glaucoma rat model. 
      METHODS: A total of 40 SD rats were selected for glaucoma model and were randomly 
      divided into 4 groups to observe protective effects of RSCs transplantation 
      combined with COP-1. RESULTS: Brain-derived neurotrophic factor (BDNF) and 
      insulin like growth factor-1 (IGF-1) were either positive in retina of RSCs 
      transplanted or COP-1 immunological treated rat. Positive rate of BDNF and IGF-1 
      and expression of mRNA and protein were significantly higher in RSCs 
      transplantation combined with COP-1 immunotherapy treated rats compared with the 
      other 3 groups, in which amount of apoptotic RGCs was lowest. CONCLUSIONS: RSCs 
      transplantation combined with COP-1 immunotherapy can promote the secretion of 
      BDNF and IGF-1. They protect RGCs in glaucoma rats in coordination, significantly 
      reduce the number of apoptosis RGCs so as to alleviate the optic nerve damage. It 
      ponits a new research direction for treatment of glaucoma.
CI  - Copyright (c) 2014 Hainan Medical College. Published by Elsevier B.V. All rights 
      reserved.
FAU - Fu, Wei-Cai
AU  - Fu WC
AD  - Department of Ophthalmology, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200127, China.
FAU - Jiang, Yan
AU  - Jiang Y
AD  - Department of Ophthalmology, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200127, China.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Ophthalmology, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200127, China. Electronic address: 28906390@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptides)
RN  - 0 (RNA, Messenger)
RN  - 5M691HL4BO (Glatiramer Acetate)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cells, Cultured
MH  - Chi-Square Distribution
MH  - Disease Models, Animal
MH  - Female
MH  - Glatiramer Acetate
MH  - Glaucoma/immunology/surgery/*therapy
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Optic Nerve Injuries/immunology/surgery/*therapy
MH  - Peptides/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retina/chemistry/*cytology
MH  - Stem Cell Transplantation/*methods
MH  - Stem Cells/cytology
OTO - NOTNLM
OT  - Glaucoma model
OT  - Immunotherapy
OT  - Polymer -1
OT  - Rat
OT  - Retinal stem cells
EDAT- 2014/02/11 06:00
MHDA- 2014/10/01 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/01/15 00:00 [revised]
PHST- 2014/02/15 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S1995-7645(14)60047-X [pii]
AID - 10.1016/S1995-7645(14)60047-X [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2014 Apr;7(4):317-20. doi: 10.1016/S1995-7645(14)60047-X.