PMID- 24508026
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20240213
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 20
IP  - 5
DP  - 2014 May
TI  - The effect of vitamin d on aldosterone and health status in patients with heart 
      failure.
PG  - 334-42
LID - S1071-9164(14)00062-1 [pii]
LID - 10.1016/j.cardfail.2014.01.019 [doi]
AB  - BACKGROUND: Vitamin D deficiency is associated with heart failure (HF) events, 
      and in animal models vitamin D down-regulates renin-angiotensin-aldosterone 
      system hormones. METHODS: Patients with New York Heart Association (NYHA) 
      functional class II-IV HF and a 25OH-D level </=37.5 ng/mL received 50,000 IU 
      vitamin D3 weekly (n = 31) or placebo (n = 33) for 6 months. Serum aldosterone, 
      renin, echocardiography, and health status were determined at baseline and 6 
      months. RESULTS: Mean age of participants was 65.9 +/- 10.4 years, 48% were women, 
      64% were African American, mean ejection fraction was 37.6 +/- 13.9%, 36% were in 
      NYHA functional class III, and 64% were in class II. The vitamin D group 
      increased serum 25OH-D (19.1 +/- 9.3 to 61.7 +/- 20.3 ng/mL) and the placebo group 
      did not (17.8 +/- 9.0 to 17.4 +/- 9.8 ng/mL). Aldosterone decreased in the vitamin D 
      group (10.0 +/- 11.9 to 6.2 +/- 11.6 ng/dL) and not in the placebo group (8.9 +/- 8.6 
      to 9.0 +/- 12.4 ng/dL; P = .02). There was no difference between groups in renin, 
      echocardiographic measures, or health status from baseline to 6 months. Modeling 
      indicated that variables which predicted change in aldosterone included receiving 
      vitamin D, increasing age, African American race, and lower glomerular filtration 
      rate. CONCLUSIONS: Vitamin D3 repletion decreases aldosterone in patients with HF 
      and low serum vitamin D. Vitamin D may be an important adjunct to standard HF 
      therapy. Further study will assess if vitamin D provides long-term benefit for 
      patients with HF.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Boxer, Rebecca S
AU  - Boxer RS
AD  - Department of Medicine, University of Colorado School of Medicine, Aurora, 
      Colorado. Electronic address: rebecca.boxer@ucdenver.edu.
FAU - Hoit, Brian D
AU  - Hoit BD
AD  - Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
FAU - Schmotzer, Brian J
AU  - Schmotzer BJ
AD  - Center for Clinical Investigation, Case Western Reserve University, Cleveland, 
      Ohio.
FAU - Stefano, Gregory T
AU  - Stefano GT
AD  - Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
FAU - Gomes, Amanda
AU  - Gomes A
AD  - McLaren Health Care, Bay City, Michigan.
FAU - Negrea, Lavinia
AU  - Negrea L
AD  - Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
LA  - eng
GR  - KL2 RR024990/RR/NCRR NIH HHS/United States
GR  - KL2 TR000440/TR/NCATS NIH HHS/United States
GR  - UL1 TR000439/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140204
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 1406-16-2 (Vitamin D)
RN  - 4964P6T9RB (Aldosterone)
SB  - IM
MH  - Aged
MH  - Aldosterone/*blood
MH  - Biomarkers/blood
MH  - Double-Blind Method
MH  - Female
MH  - *Health Status
MH  - Heart Failure/*blood/diagnosis/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Vitamin D/*therapeutic use
PMC - PMC4117205
MID - NIHMS567913
OTO - NOTNLM
OT  - Hormones
OT  - aldosterone
OT  - health status
OT  - heart failure
OT  - vitamin D
EDAT- 2014/02/11 06:00
MHDA- 2015/02/11 06:00
PMCR- 2015/05/01
CRDT- 2014/02/11 06:00
PHST- 2013/11/12 00:00 [received]
PHST- 2014/01/17 00:00 [revised]
PHST- 2014/01/28 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - S1071-9164(14)00062-1 [pii]
AID - 10.1016/j.cardfail.2014.01.019 [doi]
PST - ppublish
SO  - J Card Fail. 2014 May;20(5):334-42. doi: 10.1016/j.cardfail.2014.01.019. Epub 
      2014 Feb 4.