PMID- 24508310
OWN - NLM
STAT- MEDLINE
DCOM- 20140502
LR  - 20191210
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 226
IP  - 1
DP  - 2014 Apr 7
TI  - Manganese in exhaled breath condensate: a new marker of exposure to welding 
      fumes.
PG  - 63-9
LID - S0378-4274(14)00054-X [pii]
LID - 10.1016/j.toxlet.2014.01.034 [doi]
AB  - OBJECTIVE: To evaluate manganese in exhaled breath condensate (Mn-EBC) as an 
      indicator of exposure to fumes from metal inert gas welding process. METHODS: We 
      collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 
      days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and 
      chromium (Cr) were measured in EBC and urine samples and correlated with 
      cumulative exposure indices for the working week (CIW) and for the total welding 
      years (WY), based on duration of welding activity and atmospheric metal 
      measurements. RESULTS: Concentrations of Mn and Ni in EBC were significantly 
      higher among welders than controls whereas this difference was not significant 
      for Mn in urine. Levels of Mn and Ni in EBC were not correlated with their 
      respective levels in urine. The linear regressions found significant positive 
      coefficients between Mn-EBC, Ni-EBC, Ni-U and Cr-U concentrations and the 
      cumulative exposure indices. Taking into account tobacco use, statistical 
      analysis showed the same trends except for the relationship between Mn-U and CIW. 
      CONCLUSION: This pilot study showed that Mn-EBC, as well as Ni-EBC, can serve as 
      reliable indices of occupational exposure to welding fumes and provide 
      complimentary toxicokinetic information to that provided by urine analyses.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Hulo, Sebastien
AU  - Hulo S
AD  - Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, 
      France; CHU Lille, F-59000 Lille, France. Electronic address: 
      sebastien.hulo@univ-lille2.fr.
FAU - Cherot-Kornobis, Nathalie
AU  - Cherot-Kornobis N
AD  - Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, 
      France; CHU Lille, F-59000 Lille, France. Electronic address: 
      nathalie.cherot@univ-lille2.fr.
FAU - Howsam, Mike
AU  - Howsam M
AD  - Univ Lille Nord de France, F-59000 Lille, France; CUMA Lille, F-59006 Lille, 
      France. Electronic address: michael.howsam@univ-lille2.fr.
FAU - Crucq, Sebastien
AU  - Crucq S
AD  - ASTAV, F-59880 Valenciennes, France. Electronic address: 
      sebastien.crucq@astav.fr.
FAU - de Broucker, Virginie
AU  - de Broucker V
AD  - Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, 
      France; CHU Lille, F-59000 Lille, France. Electronic address: 
      virginie.debroucker@chru-lille.fr.
FAU - Sobaszek, Annie
AU  - Sobaszek A
AD  - Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, 
      France; CHU Lille, F-59000 Lille, France. Electronic address: 
      annie.sobaszek@univ-lille2.fr.
FAU - Edme, Jean-Louis
AU  - Edme JL
AD  - Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, 
      France; CHU Lille, F-59000 Lille, France. Electronic address: 
      jledme@univ-lille2.fr.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140205
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Biomarkers)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 7OV03QG267 (Nickel)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Biomarkers/analysis/urine
MH  - *Breath Tests
MH  - Case-Control Studies
MH  - Environmental Monitoring/*methods
MH  - *Exhalation
MH  - Humans
MH  - *Inhalation Exposure/adverse effects
MH  - Linear Models
MH  - Male
MH  - Manganese/adverse effects/*analysis/urine
MH  - Middle Aged
MH  - Nickel/adverse effects/analysis
MH  - *Occupational Exposure/adverse effects
MH  - *Occupational Health
MH  - Pilot Projects
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - *Welding
OTO - NOTNLM
OT  - Exhaled breath condensate
OT  - Manganese
OT  - Occupational exposure
OT  - Welding
EDAT- 2014/02/11 06:00
MHDA- 2014/05/03 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/07/19 00:00 [received]
PHST- 2013/12/12 00:00 [revised]
PHST- 2014/01/27 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - S0378-4274(14)00054-X [pii]
AID - 10.1016/j.toxlet.2014.01.034 [doi]
PST - ppublish
SO  - Toxicol Lett. 2014 Apr 7;226(1):63-9. doi: 10.1016/j.toxlet.2014.01.034. Epub 
      2014 Feb 5.