PMID- 24508446
OWN - NLM
STAT- MEDLINE
DCOM- 20141125
LR  - 20140325
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 51
DP  - 2014 Jun 3
TI  - Genexgenexgender interaction of BDNF and COMT genotypes associated with panic 
      disorder.
PG  - 119-25
LID - S0278-5846(14)00028-1 [pii]
LID - 10.1016/j.pnpbp.2014.01.020 [doi]
AB  - Genetic and gender differences are among the factors that have a role in the 
      etiology of panic disorder (PD). It is thought that PD is related to 
      neurotransmitter pathways, such as brain-derived neurotrophic factor (BDNF) and 
      catechol-O-methyltransferase (COMT), both of which are involved in the regulation 
      of the monoamine mechanism. We examined the interactions of BDNF, COMT and gender 
      differences in terms of personality characteristics in PD. The subjects were 470 
      patients (178 men, 292 women) with a DSM-IV diagnosis of PD, and 458 healthy 
      controls (195 men, 263 women). The subjects were further clinically characterized 
      using the Revised NEO Personality Inventory (NEO-PI-R) and State-Trait Anxiety 
      Inventory (STAI). COMT Val158Met polymorphisms (rs4680) and BDNF Val66Met 
      (rs6265) polymorphisms were genotyped using allelic discrimination by a real-time 
      PCR assay. A multivariate analysis of covariance (MANCOVA) was performed with 
      STAI and NEO-PI-R scores as the dependent factor, gender and genotyping groups 
      (BDNF and COMT) as fixed factors, and the covariate of age in the PD and healthy 
      control groups. Post hoc MANCOVA tests were conducted to evaluate COMT x BDNF 
      interactions. An interaction of BDNF x COMT x gender was confirmed in the PD 
      group by MANCOVA on STAI scores and NEO-PI-R Neuroticism and Extraversion scores, 
      whereas no association of such interactions was observed in the healthy controls. 
      The anxiety sensitivity of the COMT Met+BDNF Val/Val carriers was higher than 
      that of the COMT Val/Val+BDNF Val/Val carriers by post hoc MANCOVA. A significant 
      BDNF x COMT x gender interaction was observed in the PD patients but not in the 
      controls. Our findings partly demonstrated the involvement of a gene x gene x 
      gender interaction in the pathogenesis of PD.
CI  - Copyright (c) 2014. Published by Elsevier Inc.
FAU - Konishi, Yoshiaki
AU  - Konishi Y
AD  - Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, 
      Brain Science and Animal Model Research Center (BSAM), Mie University, Mie, 
      Japan.
FAU - Tanii, Hisashi
AU  - Tanii H
AD  - Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, 
      Brain Science and Animal Model Research Center (BSAM), Mie University, Mie, 
      Japan. Electronic address: h-tanii@clin.medic.mie-u.ac.jp.
FAU - Otowa, Takeshi
AU  - Otowa T
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Sasaki, Tsukasa
AU  - Sasaki T
AD  - Laboratory of Health Education, Graduate School of Education, The University of 
      Tokyo, Tokyo, Japan.
FAU - Tochigi, Mamoru
AU  - Tochigi M
AD  - Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
FAU - Umekage, Tadashi
AU  - Umekage T
AD  - Division for Environment, Health and Safety, The University of Tokyo, Tokyo, 
      Japan.
FAU - Motomura, Eishi
AU  - Motomura E
AD  - Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, 
      Brain Science and Animal Model Research Center (BSAM), Mie University, Mie, 
      Japan.
FAU - Shiroyama, Takashi
AU  - Shiroyama T
AD  - Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, 
      Brain Science and Animal Model Research Center (BSAM), Mie University, Mie, 
      Japan.
FAU - Kaiya, Hisanobu
AU  - Kaiya H
AD  - Research Center for Panic Disorder, Nagoya Mental Clinic, Aichi, Japan.
FAU - Okazaki, Yuji
AU  - Okazaki Y
AD  - Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
FAU - Okada, Motohiro
AU  - Okada M
AD  - Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, 
      Brain Science and Animal Model Research Center (BSAM), Mie University, Mie, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140204
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Panic Disorder/*genetics
MH  - Personality Inventory
MH  - Polymorphism, Genetic/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Psychological Tests
MH  - *Sex Characteristics
OTO - NOTNLM
OT  - BDNF
OT  - COMT
OT  - Gender
OT  - Genexgenexgender interaction
OT  - Panic disorder
EDAT- 2014/02/11 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/11/08 00:00 [received]
PHST- 2014/01/29 00:00 [revised]
PHST- 2014/01/29 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0278-5846(14)00028-1 [pii]
AID - 10.1016/j.pnpbp.2014.01.020 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:119-25. doi: 
      10.1016/j.pnpbp.2014.01.020. Epub 2014 Feb 4.