PMID- 24508447
OWN - NLM
STAT- MEDLINE
DCOM- 20141125
LR  - 20140325
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 51
DP  - 2014 Jun 3
TI  - Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF 
      mRNA expression in rat hippocampus.
PG  - 126-32
LID - S0278-5846(14)00024-4 [pii]
LID - 10.1016/j.pnpbp.2014.01.016 [doi]
AB  - It is known that lipopolysaccharide (LPS) treatment induces neuroinflammation and 
      memory deterioration. One of the mechanisms may be the interference with 
      brain-derived neurotrophic factor (BDNF) gene expression and function. 
      Lipopolysaccharide (3 mug/kg and 10 mug/kg) was unilaterally injected into the 
      substantia nigra of adult male Wistar rats. Pergolide-induced rotational behavior 
      test was employed to validate unilateral damage to the dopamine nigrostriatal 
      neurons. Anxiety-depression-like behaviors were studied by means of elevated 
      plus-maze task and forced swimming test, as animal models of anxiety and 
      depression. Rats given LPS exhibited the following: decrease of the percentage of 
      the time spent and the number of entries in the open arm within elevated 
      plus-maze test and decrease of swimming and increase of immobility times within 
      forced swimming test. In addition, these behaviors are associated with decreased 
      BDNF mRNA expression in rat hippocampus. Taken together, these data indicate that 
      intranigral LPS infusion influences the induction of BDNF mRNA expression within 
      hippocampus which contributes to observed behavioral responses in rats, with 
      relevance for Parkinson's disease conditions.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Hritcu, Lucian
AU  - Hritcu L
AD  - Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania. 
      Electronic address: hritcu@uaic.ro.
FAU - Gorgan, Lucian Dragos
AU  - Gorgan LD
AD  - Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140204
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Anxiety/chemically induced/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Depression/chemically induced/*pathology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/*metabolism
MH  - Lipopolysaccharides/toxicity
MH  - Male
MH  - Maze Learning
MH  - Motor Activity/drug effects/physiology
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Substantia Nigra/drug effects
MH  - Swimming/psychology
OTO - NOTNLM
OT  - Anxiety
OT  - BDNF mRNA expression
OT  - Depression
OT  - Lipopolysaccharide
OT  - Parkinson's disease
EDAT- 2014/02/11 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/09/09 00:00 [received]
PHST- 2014/01/15 00:00 [revised]
PHST- 2014/01/26 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0278-5846(14)00024-4 [pii]
AID - 10.1016/j.pnpbp.2014.01.016 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:126-32. doi: 
      10.1016/j.pnpbp.2014.01.016. Epub 2014 Feb 4.