PMID- 24508745
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20140331
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 265
DP  - 2014 Apr 18
TI  - Noradrenergic modulation of neuronal responses to n-methyl-d-aspartate in the 
      vestibular nuclei: an electrophysiological and immunohistochemical study.
PG  - 172-83
LID - S0306-4522(14)00075-X [pii]
LID - 10.1016/j.neuroscience.2014.01.054 [doi]
AB  - Excitatory responses evoked by N-methyl-d-aspartate (NMDA) in the vestibular 
      nuclei (VN) of the rat were studied in vivo during microiontophoretic application 
      of noradrenaline (NA) and/or its agonists and antagonists. Ejection of 
      NA-modified excitatory responses mediated by NMDA receptors (NMDAR) in all 
      neurons tested; the effect was enhancement in 59% of cases and depression in the 
      remaining 41%. Enhancements prevailed in all VN with the exception of the lateral 
      vestibular nucleus, where both effects were recorded in an equal number of cases. 
      The enhancing action of NA on NMDAR-mediated responses was mimicked by the 
      noradrenergic beta-receptor agonist isoproterenol, the beta1 specific agonist 
      denopamine and the alpha2 agonist clonidine. These effects were blocked 
      respectively by the generic beta-receptor antagonist timolol, the beta1 
      antagonist atenolol and the alpha2 antagonist yohimbine. In contrast, application 
      of the alpha1 receptor agonist cirazoline and the specific alpha1 antagonist 
      prazosin respectively mimicked and partially antagonized the depression of 
      NMDAR-mediated excitations induced by NA. Double-labeling immunohistochemical 
      techniques demonstrated broad colocalization of NMDAR (specifically NR1 and NR2 
      subunits) with noradrenergic receptors (alpha1, alpha2 and beta1) in many VN 
      neurons; only minor differences were found between nuclei. These results indicate 
      that NA can produce generalized modulation of NMDAR-mediated excitatory 
      neurotransmission in VN, which may in turn modify synaptic plasticity within the 
      nuclei.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Barresi, M
AU  - Barresi M
AD  - Department of Biomedical Sciences, Section of Physiology, University of Catania, 
      Italy. Electronic address: mbarresi@unict.it.
FAU - Grasso, C
AU  - Grasso C
AD  - Department of Biomedical Sciences, Section of Physiology, University of Catania, 
      Italy. Electronic address: clgrasso@unict.it.
FAU - Licata, F
AU  - Licata F
AD  - Department of Biomedical Sciences, Section of Physiology, University of Catania, 
      Italy. Electronic address: flicata@unict.it.
FAU - Li Volsi, G
AU  - Li Volsi G
AD  - Department of Biomedical Sciences, Section of Physiology, University of Catania, 
      Italy. Electronic address: glivolsi@unict.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140207
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Electrophysiological Phenomena
MH  - Immunohistochemistry
MH  - Male
MH  - N-Methylaspartate/pharmacology
MH  - Neurons/drug effects/*physiology
MH  - Norepinephrine/agonists/antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adrenergic/analysis/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/analysis/*metabolism
MH  - Vestibular Nuclei/drug effects/*metabolism
OTO - NOTNLM
OT  - NMDA receptors
OT  - firing rate
OT  - microiontophoresis
OT  - noradrenaline
OT  - vestibular complex
EDAT- 2014/02/11 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2014/01/23 00:00 [revised]
PHST- 2014/01/29 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0306-4522(14)00075-X [pii]
AID - 10.1016/j.neuroscience.2014.01.054 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Apr 18;265:172-83. doi: 10.1016/j.neuroscience.2014.01.054. 
      Epub 2014 Feb 7.