PMID- 24510074
OWN - NLM
STAT- MEDLINE
DCOM- 20150522
LR  - 20240511
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Print)
IS  - 1073-8584 (Linking)
VI  - 20
IP  - 5
DP  - 2014 Oct
TI  - Estrogen receptors, the hippocampus, and memory.
PG  - 534-45
LID - 10.1177/1073858413519865 [doi]
AB  - Estradiol effects on memory depend on hormone levels and the interaction of 
      different estrogen receptors within neural circuits. Estradiol induces gene 
      transcription and rapid membrane signaling mediated by estrogen receptor-alpha 
      (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein 
      coupled estrogen receptor, each with distinct distributions and ability to 
      influence estradiol-dependent signaling. Investigations using receptor specific 
      agonists suggest that all three receptors rapidly activate kinase-signaling and 
      have complex dose-dependent influences on memory. Research employing receptor 
      knockout mice demonstrate that ERalpha maintains transcription and memory as 
      estradiol levels decline. This work indicates a regulatory role of ERbeta in 
      transcription and cognition, which depends on estradiol levels and the function 
      of ERalpha. The regulatory role of ERbeta is due in part to ERbeta acting as a negative 
      regulator of ERalpha-mediated transcription. Vector-mediated expression of estrogen 
      receptors in the hippocampus provides an innovative research approach and 
      suggests that memory depends on the relative expression of ERalpha and ERbeta 
      interacting with estradiol levels. Notably, the ability of estradiol to improve 
      cognition declines with advanced age along with decreased expression of estrogen 
      receptors. Thus, it will be important for future research to determine the 
      mechanisms that regulate estrogen receptor expression during aging.
CI  - (c) The Author(s) 2014.
FAU - Bean, Linda A
AU  - Bean LA
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL, USA.
FAU - Ianov, Lara
AU  - Ianov L
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL, USA Genetics and Genomics Program, Genetics Institute, 
      University of Florida, Gainesville, FL, USA.
FAU - Foster, Thomas C
AU  - Foster TC
AD  - Department of Neuroscience, McKnight Brain Institute, University of Florida, 
      Gainesville, FL, USA Genetics and Genomics Program, Genetics Institute, 
      University of Florida, Gainesville, FL, USA foster1@ufl.edu.
LA  - eng
GR  - R01AG037984/AG/NIA NIH HHS/United States
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - R01 AG037984/AG/NIA NIH HHS/United States
GR  - R37 AG036800/AG/NIA NIH HHS/United States
GR  - R37AG036800/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140207
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Cognition/physiology
MH  - Cognition Disorders/physiopathology
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Memory/*physiology
MH  - Receptors, Estrogen/*metabolism
PMC - PMC4317255
MID - NIHMS657897
OTO - NOTNLM
OT  - aging
OT  - estrogen
OT  - estrogen receptor-alpha (ERalpha)
OT  - hippocampus
OT  - memory
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2014/02/11 06:00
MHDA- 2015/05/23 06:00
PMCR- 2015/02/04
CRDT- 2014/02/11 06:00
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
PHST- 2015/02/04 00:00 [pmc-release]
AID - 1073858413519865 [pii]
AID - 10.1177/1073858413519865 [doi]
PST - ppublish
SO  - Neuroscientist. 2014 Oct;20(5):534-45. doi: 10.1177/1073858413519865. Epub 2014 
      Feb 7.