PMID- 24510327
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20141212
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 43
IP  - 4
DP  - 2013 Dec
TI  - Effects of hyperbaric oxygen on blood glucose levels in patients with diabetes 
      mellitus, stroke or traumatic brain injury and healthy volunteers: a prospective, 
      crossover, controlled trial.
PG  - 218-21
AB  - INTRODUCTION: A decrease in blood glucose levels (BGL) during hyperbaric oxygen 
      treatment (HBOT) is a well-recognised phenomenon, but studies of this are limited 
      and inconclusive. This study evaluated the effect of HBOT on BGL in patients with 
      diabetes mellitus (DM), traumatic brain injury (TBI) or stroke and healthy 
      volunteers in a prospective, open, controlled trial. METHODS: Thirty-nine 
      participants were enrolled and evaluated twice: once during HBOT (90 minutes at 
      203 kPa), and once during a control session on normobaric air. Sessions were held 
      up to two weeks apart and participants were instructed to eat the same diet. BGL 
      was measured before, during and at the completion of each session. RESULTS: For 
      the whole study group, there was a small but statistically significant decrease 
      in BGL in both the HBOT (7.27 +/- 3.66 mmol(-)(1) before to 6.71 +/- 3.88 mmol (-)(1) after, 
      P = 0.037) and control (air) sessions (7.43 +/- 3.49 mmol L(-)(1) before to 6.71 +/- 3.77 
      mmol L(-)(1) after, P = 0.004). This fall did not differ between the two conditions 
      (P = 0.59). Examining the three groups separately, BGL fell in all three 
      subgroups, but this fall was only statistically significant for the air session 
      in the diabetic group. There were no statistically significant differences in the 
      BGL reduction when HBOT was compared to normobaric air in any of the three 
      subgroups. CONCLUSIONS: BGL may decrease during HBOT and accordingly it should be 
      monitored before entering the chamber. However, this decrease in BGL should 
      probably not be attributed to the hyperbaric environment per se.
FAU - Peleg, Ronit Koren
AU  - Peleg RK
AD  - Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Department of Internal 
      Medicine A, Assaf Harofeh Medical Center, Zerifin 70300, Israel, Phone: 
      +972-(0)50-5191-651, Fax: +972-(0)89778359, E-mail: ronitkoren@gmail.com.
FAU - Fishlev, Gregori
AU  - Fishlev G
AD  - The Institute of Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin.
FAU - Bechor, Yair
AU  - Bechor Y
AD  - The Institute of Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin.
FAU - Bergan, Jacob
AU  - Bergan J
AD  - The Institute of Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin.
FAU - Friedman, Mony
AU  - Friedman M
AD  - The Institute of Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin.
FAU - Koren, Shlomit
AU  - Koren S
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel. 
      Affiliated to Sackler School of Medicine, Tel Aviv University, Israel, Research 
      and Development Unit, Assaf Harofeh Medical Center, Zerifin.
FAU - Tirosh, Amit
AU  - Tirosh A
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel. 
      Affiliated to Sackler School of Medicine, Tel Aviv University, Israel, Research 
      and Development Unit, Assaf Harofeh Medical Center, Zerifin.
FAU - Efrati, Shai
AU  - Efrati S
AD  - Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, The Institute of 
      Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin, Research and 
      Development Unit, Assaf Harofeh Medical Center, Zerifin, Sagol School of 
      Neuroscience, Tel-Aviv University, Tel-Aviv.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Blood Glucose/*analysis/metabolism
MH  - Brain Injuries/*blood/therapy
MH  - Case-Control Studies
MH  - Cross-Over Studies
MH  - Diabetes Mellitus/*blood
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Stroke/*blood/therapy
OTO - NOTNLM
OT  - Hyperbaric oxygen
OT  - blood glucose
OT  - blood pressure
OT  - heart rate
OT  - prospective controlled trial
EDAT- 2014/02/11 06:00
MHDA- 2014/03/13 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/05/28 00:00 [received]
PHST- 2013/10/20 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
PST - ppublish
SO  - Diving Hyperb Med. 2013 Dec;43(4):218-21.