PMID- 24510758
OWN - NLM
STAT- MEDLINE
DCOM- 20141215
LR  - 20220410
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 119
IP  - 9
DP  - 2014 Sep
TI  - Volumetric and positional changes of planning target volumes and organs at risk 
      using computed tomography imaging during intensity-modulated radiation therapy 
      for head-neck cancer: an "old" adaptive radiation therapy approach.
PG  - 714-20
LID - 10.1007/s11547-014-0386-z [doi]
AB  - PURPOSE: This study aimed to assess, in a department of radiation oncology not 
      equipped with in-room imaging systems, volumetric and positional changes of 
      planning target volumes (PTVs) and organs at risk in head and neck (H&N) cancer 
      patients treated with intensity-modulated radiation therapy (IMRT), using 
      consecutive off-board computed tomography (CT) imaging. Dosimetric aspects were 
      not investigated. MATERIALS AND METHODS: Ten patients with H&N cancer underwent 
      CT re-scanning at 3, 5, and 7 weeks. Positional changes of the PTVs and parotid 
      glands as distances relative to the virtual isocentre were determined. The 
      parotids glands (PGs) were re-delineated on each CT set and volume differences 
      were computed. Anterior-posterior (AP) and latero-lateral (LL) displacements for 
      the spinal cord at C1 and C6 level were calculated. Changes in patient body 
      contours were evaluated by comparing the volumes within the external skin 
      outline. RESULTS: Apart from two patients requiring re-planning due to 
      substantial weight loss, our results evidenced no significant shifts of PTVs and 
      PGs. PG volume decreased with a trend in volume reduction for the ipsilateral 
      parotid. No significant shift of spinal cord at C1 and C6 level was detected, in 
      either the AP or LL direction. The collected data demonstrated a trend in 
      external skin contour volume loss. CONCLUSIONS: Our preliminary results reflect 
      the literature data and indicate that an off-line adaptive RT approach is 
      appropriate in clinical practice.
FAU - Reali, Alessia
AU  - Reali A
AD  - Department of Oncology, Radiation Oncology, University of Turin, S. Luigi Gonzaga 
      Hospital, Orbassano, Turin, Italy.
FAU - Anglesio, Silvia Maria
AU  - Anglesio SM
FAU - Mortellaro, Gianluca
AU  - Mortellaro G
FAU - Allis, Simona
AU  - Allis S
FAU - Bartoncini, Sara
AU  - Bartoncini S
FAU - Ruo Redda, Maria Grazia
AU  - Ruo Redda MG
FAU - Arcadipane, Francesca
AU  - Arcadipane F
LA  - eng
PT  - Journal Article
DEP - 20140208
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
EIN - Radiol Med. 2014 Sep;119(9):727
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Head and Neck Neoplasms/*diagnostic imaging/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parotid Gland/diagnostic imaging/radiation effects
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Spinal Cord/diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2014/02/11 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/02/11 06:00
PHST- 2013/05/24 00:00 [received]
PHST- 2013/08/22 00:00 [accepted]
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1007/s11547-014-0386-z [doi]
PST - ppublish
SO  - Radiol Med. 2014 Sep;119(9):714-20. doi: 10.1007/s11547-014-0386-z. Epub 2014 Feb 
      8.