PMID- 24510998
OWN - NLM
STAT- MEDLINE
DCOM- 20140327
LR  - 20151119
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 34
IP  - 2
DP  - 2014 Feb
TI  - Differential expression of vascular endothelial growth factor in high- and 
      low-metastasis cell lines of salivary gland adenoid cystic carcinoma.
PG  - 671-7
AB  - We used high- (ACCM) and low- (ACC2) metastasis cell lines of human adenoid 
      cystic carcinoma (ACC) as an experimental model to study metastatic mechanisms 
      and compare their expression levels for angiogenic-related factor vascular 
      endothelial growth factor (VEGF). By using a series of extensive analyses, 
      hypoxia-inducible factor-1 (HIF-1) alpha-dependent VEGF expression levels were 
      observed to be higher in ACCM cell lines, increasing the possible development of 
      tumor metastasis, compared to ACC2 cell lines. Our findings provide the novel 
      insight that HIF-1alpha-dependent VEGF overexpression under hypoxic conditions shows 
      to some extent associations with the metastatic tendency of ACC cells and may 
      function as a potential target for ACC therapy.
FAU - Kondo, Seiji
AU  - Kondo S
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa 
      University, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan. 
      seikondo12@dent.showa-u.ac.jp.
FAU - Mukudai, Yoshiki
AU  - Mukudai Y
FAU - Soga, Daisuke
AU  - Soga D
FAU - Nishida, Takashi
AU  - Nishida T
FAU - Takigawa, Masaharu
AU  - Takigawa M
FAU - Shirota, Tatsuo
AU  - Shirota T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (RNA, Messenger)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Biomarkers, Tumor/biosynthesis/genetics
MH  - Carcinoma, Adenoid Cystic/*metabolism/*pathology
MH  - Cell Hypoxia/physiology
MH  - Cell Line, Tumor
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Neoplasm Metastasis
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Salivary Gland Neoplasms/*metabolism/*pathology
MH  - Vascular Endothelial Growth Factor A/*biosynthesis/genetics
OTO - NOTNLM
OT  - Hypoxia
OT  - adenoid cystic carcinoma
OT  - vascular endothelial growth factor
EDAT- 2014/02/11 06:00
MHDA- 2014/03/29 06:00
CRDT- 2014/02/11 06:00
PHST- 2014/02/11 06:00 [entrez]
PHST- 2014/02/11 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 34/2/671 [pii]
PST - ppublish
SO  - Anticancer Res. 2014 Feb;34(2):671-7.