PMID- 24512272
OWN - NLM
STAT- MEDLINE
DCOM- 20141003
LR  - 20211021
IS  - 1476-7120 (Electronic)
IS  - 1476-7120 (Linking)
VI  - 12
DP  - 2014 Feb 10
TI  - Different contribution of extent of myocardial injury to left ventricular 
      systolic and diastolic function in early reperfused acute myocardial infarction.
PG  - 6
LID - 10.1186/1476-7120-12-6 [doi]
AB  - BACKGROUND: We sought to investigate the influence of the extent of myocardial 
      injury on left ventricular (LV) systolic and diastolic function in patients after 
      reperfused acute myocardial infarction (AMI). METHODS: Thirty-eight reperfused 
      AMI patients underwent cardiac magnetic resonance (CMR) imaging after 
      percutaneous coronary revascularization. The extent of myocardial edema and 
      scarring were assessed by T2 weighted imaging and late gadolinium enhancement 
      (LGE) imaging, respectively. Within a day of CMR, echocardiography was done. 
      Using 2D speckle tracking analysis, LV longitudinal, circumferential strain, and 
      twist were measured. RESULTS: Extent of LGE were significantly correlated with LV 
      systolic functional indices such as ejection fraction (r = -0.57, p < 0.001), 
      regional wall motion score index (r = 0.52, p = 0.001), and global longitudinal 
      strain (r = 0.56, p < 0.001). The diastolic functional indices significantly 
      correlated with age (r = -0.64, p < 0.001), LV twist (r = -0.39, p = 0.02), 
      average non-infarcted myocardial circumferential strain (r = -0.52, p = 0.001), 
      and LV end-diastolic wall stress index (r = -0.47, p = 0.003 with e') but not or 
      weakly with extent of LGE. In multivariate analysis, age and non-infarcted 
      myocardial circumferential strain independently correlated with diastolic 
      functional indices rather than extent of injury. CONCLUSIONS: In patients with 
      timely reperfused AMI, not only extent of myocardial injury but also age and 
      non-infarcted myocardial function were more significantly related to LV chamber 
      diastolic function.
FAU - Chung, Hyemoon
AU  - Chung H
FAU - Yoon, Ji-Hyun
AU  - Yoon JH
FAU - Yoon, Young Won
AU  - Yoon YW
FAU - Park, Chul Hwan
AU  - Park CH
FAU - Ko, Eun Jung
AU  - Ko EJ
FAU - Kim, Jong Youn
AU  - Kim JY
FAU - Min, Pil-Ki
AU  - Min PK
FAU - Kim, Tae Hoon
AU  - Kim TH
FAU - Lee, Byoung Kwon
AU  - Lee BK
FAU - Hong, Bum-Kee
AU  - Hong BK
FAU - Rim, Se-Joong
AU  - Rim SJ
FAU - Kwon, Hyuck Moon
AU  - Kwon HM
FAU - Choi, Eui-Young
AU  - Choi EY
AD  - Division of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei 
      University College of Medicine, Seoul, Republic of Korea. choi0928@yuhs.ac.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140210
PL  - England
TA  - Cardiovasc Ultrasound
JT  - Cardiovascular ultrasound
JID - 101159952
SB  - IM
MH  - Elasticity Imaging Techniques/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/diagnostic imaging/*physiopathology
MH  - Myocardial Stunning/diagnostic imaging/*etiology/*physiopathology
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnostic imaging/etiology/*physiopathology
PMC - PMC3922533
EDAT- 2014/02/12 06:00
MHDA- 2014/10/04 06:00
PMCR- 2014/02/10
CRDT- 2014/02/12 06:00
PHST- 2013/10/21 00:00 [received]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/10/04 06:00 [medline]
PHST- 2014/02/10 00:00 [pmc-release]
AID - 1476-7120-12-6 [pii]
AID - 10.1186/1476-7120-12-6 [doi]
PST - epublish
SO  - Cardiovasc Ultrasound. 2014 Feb 10;12:6. doi: 10.1186/1476-7120-12-6.