PMID- 24512293
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20191210
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 31
IP  - 5
DP  - 2014
TI  - Quantification of aristolochic acids I and II in herbal dietary supplements by 
      ultra-high-performance liquid chromatography-multistage fragmentation mass 
      spectrometry.
PG  - 784-91
LID - 10.1080/19440049.2014.892215 [doi]
AB  - A rapid, selective and sensitive ultra-high-performance liquid 
      chromatography-multistage fragmentation mass spectrometry (UHPLC-MS(3)) method was 
      developed and evaluated for the determination of aristolochic acids I and II (AA 
      I and II) in herbal dietary supplements. A hybrid triple quadrupole/linear 
      ion-trap mass spectrometry was used to monitor MS(3) ion transitions m/z 359.2 > 
      298.1 > 268.0 and m/z 329.2 > 268.2 > 238.0 to detect AA I and II, respectively. 
      The extraction and clean-up of target analytes from dry powdered samples was 
      performed using the quick, easy, cheap, effective, rugged and safe (QuEChERS) 
      procedure. Herbal liquid extracts were analysed directly. Average recoveries 
      ranged from 89% to 112%, with relative standard deviations (RSDs) ranging from 3% 
      to 16%. Limits of quantification (LOQs) estimated for three selected matrices 
      were as follows (AA I/II): 5/10 ng g(-)(1) (tablets); 25/50 ng g(-)(1) (capsules); and 
      2.5/5.0 ng ml(-)(1) (liquid herbal extract). The method was applied in a limited 
      survey of 30 herbal products marketed in the United States via the Internet. AA I 
      and II were detected in 20% and 7%, respectively, of tested samples.
FAU - Vaclavik, Lukas
AU  - Vaclavik L
AD  - a Center for Food Safety and Applied Nutrition, Office of Regulatory Science , US 
      Food and Drug Administration , College Park , MD , USA.
FAU - Krynitsky, Alexander J
AU  - Krynitsky AJ
FAU - Rader, Jeanne I
AU  - Rader JI
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140408
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Aristolochic Acids)
RN  - 0 (Carcinogens)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Preparations)
RN  - 0 (Poisons)
RN  - 94218WFP5T (aristolochic acid I)
RN  - BB72D5PU2Y (aristolochic acid II)
SB  - IM
MH  - Analytic Sample Preparation Methods
MH  - Aristolochic Acids/*analysis/chemistry
MH  - Carcinogens/*analysis/chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Dietary Supplements/*analysis/economics
MH  - Drug Contamination
MH  - Drugs, Chinese Herbal/chemistry/economics
MH  - *Food Contamination
MH  - Food Inspection/*methods
MH  - Internet
MH  - Limit of Detection
MH  - Plant Extracts/chemistry/economics
MH  - Plant Preparations/*chemistry/economics
MH  - Poisons/analysis/chemistry
MH  - Reproducibility of Results
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Tandem Mass Spectrometry
MH  - United States
OTO - NOTNLM
OT  - LC-MS
OT  - aristolochic acid
OT  - herbal dietary supplements
EDAT- 2014/02/12 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/02/12 06:00
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1080/19440049.2014.892215 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(5):784-91. 
      doi: 10.1080/19440049.2014.892215. Epub 2014 Apr 8.