PMID- 24512965 OWN - NLM STAT- MEDLINE DCOM- 20150219 LR - 20240321 IS - 1872-9738 (Electronic) IS - 0892-0362 (Print) IS - 0892-0362 (Linking) VI - 42 DP - 2014 Mar-Apr TI - Correspondence of parent report and laboratory measures of inattention and hyperactivity in children with heavy prenatal alcohol exposure. PG - 43-50 LID - S0892-0362(14)00018-X [pii] LID - 10.1016/j.ntt.2014.01.007 [doi] AB - Clinical research and practice support a multi-method approach to validating behavioral problems in children. We examined whether parent-reported symptoms of hyperactivity and inattention (using the Disruptive Behavior Disorder Rating Scale) were substantiated by objective laboratory measures [hyperactivity measured by wrist-worn actigraphy (ACT) and inattention assessed using a 20-minute continuous performance task (CPT)] in three age- and demographically-matched groups of school-age children: children with prenatal alcohol exposure (AE), non-exposed children with idiopathic ADHD (ADHD), and controls (CON). Results indicated that the clinical groups (AE, ADHD) had significantly higher parent-reported levels for both domains compared to the CON group, and did not differ from each other. On the laboratory measures, the clinical groups were more inattentive than controls on the CPT, but did not differ from each other. In contrast, the ADHD group had higher objective activity on the ACT than AE and CON, which did not differ from each other. Thus, laboratory measures differentially validated parent reports in a group-dependent manner. Actigraphy substantiated parent-reported hyperactivity for children in the ADHD group but not for children in the AE group, while the CPT validated parent-reported inattention for both clinical groups. Although the majority of children in the AE group met the criteria for ADHD, objective activity levels were not different from controls, indicating that hyperactivity may be a less prominent feature in the AE group. Thus, while there is considerable overlap between the effects of prenatal alcohol exposure and ADHD, differences in behavioral profiles may be clinically useful in differential diagnosis. Further, these data indicate that objective measures should be used to validate parent reports. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Glass, Leila AU - Glass L AD - Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6330 Alvarado Court, Suite 100, San Diego, CA 92120, USA. Electronic address: lglass@mail.sdsu.edu. FAU - Graham, Diana M AU - Graham DM AD - Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6330 Alvarado Court, Suite 100, San Diego, CA 92120, USA. Electronic address: dgraham@mail.sdsu.edu. FAU - Deweese, Benjamin N AU - Deweese BN AD - Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6330 Alvarado Court, Suite 100, San Diego, CA 92120, USA. Electronic address: bdeweese@mail.sdsu.edu. FAU - Jones, Kenneth Lyons AU - Jones KL AD - University of California, San Diego, School of Medicine, Department of Pediatrics, San Diego, CA 92093, USA. Electronic address: klyons@ucsd.edu. FAU - Riley, Edward P AU - Riley EP AD - Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6330 Alvarado Court, Suite 100, San Diego, CA 92120, USA. Electronic address: eriley@mail.sdsu.edu. FAU - Mattson, Sarah N AU - Mattson SN AD - Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6330 Alvarado Court, Suite 100, San Diego, CA 92120, USA. Electronic address: sarah.mattson@sdsu.edu. LA - eng GR - F31 AA022261/AA/NIAAA NIH HHS/United States GR - U01 AA014834/AA/NIAAA NIH HHS/United States GR - T32 AA013525/AA/NIAAA NIH HHS/United States GR - U24 AA014818/AA/NIAAA NIH HHS/United States GR - U24 AA014811/AA/NIAAA NIH HHS/United States GR - U24 AA014815/AA/NIAAA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20140207 PL - United States TA - Neurotoxicol Teratol JT - Neurotoxicology and teratology JID - 8709538 SB - IM MH - Actigraphy MH - Adolescent MH - Alcoholism/complications MH - Attention Deficit Disorder with Hyperactivity/diagnosis/*etiology/*psychology MH - Case-Control Studies MH - Child MH - Female MH - Fetal Alcohol Spectrum Disorders/diagnosis/*psychology MH - Humans MH - Male MH - Neuropsychological Tests MH - Parents/psychology MH - Pregnancy MH - Prenatal Exposure Delayed Effects/diagnosis/*etiology/*psychology MH - Task Performance and Analysis PMC - PMC3989839 MID - NIHMS570774 OTO - NOTNLM OT - Attention-deficit/hyperactivity disorder (ADHD) OT - Fetal alcohol spectrum disorders (FASD) OT - Fetal alcohol syndrome (FAS) OT - Hyperactivity OT - Inattention OT - Prenatal alcohol exposure COIS- Conflict of Interest Statement The authors declare that there are no conflicts of interest. EDAT- 2014/02/12 06:00 MHDA- 2015/02/20 06:00 PMCR- 2015/03/01 CRDT- 2014/02/12 06:00 PHST- 2013/09/24 00:00 [received] PHST- 2013/12/20 00:00 [revised] PHST- 2014/01/29 00:00 [accepted] PHST- 2014/02/12 06:00 [entrez] PHST- 2014/02/12 06:00 [pubmed] PHST- 2015/02/20 06:00 [medline] PHST- 2015/03/01 00:00 [pmc-release] AID - S0892-0362(14)00018-X [pii] AID - 10.1016/j.ntt.2014.01.007 [doi] PST - ppublish SO - Neurotoxicol Teratol. 2014 Mar-Apr;42:43-50. doi: 10.1016/j.ntt.2014.01.007. Epub 2014 Feb 7.