PMID- 24513009
OWN - NLM
STAT- MEDLINE
DCOM- 20140820
LR  - 20220316
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 32
IP  - 15
DP  - 2014 Mar 26
TI  - The link between genetic variation and variability in vaccine responses: 
      systematic review and meta-analyses.
PG  - 1661-9
LID - S0264-410X(14)00109-1 [pii]
LID - 10.1016/j.vaccine.2014.01.057 [doi]
AB  - Although immune response to vaccines can be influenced by several parameters, 
      human genetic variations are thought to strongly influence the variability in 
      vaccine responsiveness. Systematic reviews and meta-analyses are needed to 
      clarify the genetic contribution to this variability, which may affect the 
      efficacy of existing vaccines. We performed a systematic literature search to 
      identify all studies describing the associations of allelic variants or single 
      nucleotide polymorphisms in immune response genes with vaccine responses until 
      July 2013. The studies fulfilling inclusion criteria were meta-analyzed. Thirteen 
      studies (11,686 subjects) evaluated the associations of human leukocyte antigen 
      (HLA) and other immunity gene variations with the responses to single vaccines, 
      including MMR-II (measles and rubella virus), HepB (hepatitis virus), influenza 
      virus, and MenC (serogroup C meningococcus) vaccines. Seven HLA genetic variants 
      were included in the meta-analyses. The pooled ORs showed that DRB1*07 (2.46 [95% 
      CI=1.60-3.77]; P for heterogeneity=0.117; I(2)=49.1%), DQA1*02:01 (2.21 [95% 
      CI=1.22-4.00]; P for heterogeneity=0.995; I(2)=0.0%), DQB1*02:01 (2.03 [95% 
      CI=1.35-3.07]; P for heterogeneity=0.449; I(2)=0.0%), and DQB1*03:03 (3.31 [95% 
      CI=1.12-9.78]; P for heterogeneity=0.188; I(2)=42.4%) were associated with a 
      significant decrease of antibody responses to MMR-II, HepB, and influenza 
      vaccines. The pooled ORs showed that DRB1*13 (0.52 [95% CI=0.32-0.84]; P for 
      heterogeneity=0.001; I(2)=85.1%) and DRB1*13:01 (0.19 [95% CI=0.06-0.58]; P for 
      heterogeneity=0.367; I(2)=0.0%) were associated with a significant increase of 
      antibody responses to the above vaccines. While our findings reinforce the 
      concept that individuals with a particular HLA allelic composition are more 
      likely to respond efficiently to vaccines, future studies should be encouraged to 
      further elucidate the link between genetic variation and variability of the human 
      immune response to vaccines.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Posteraro, Brunella
AU  - Posteraro B
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy.
FAU - Pastorino, Roberta
AU  - Pastorino R
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy.
FAU - Di Giannantonio, Paolo
AU  - Di Giannantonio P
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy.
FAU - Ianuale, Carolina
AU  - Ianuale C
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy.
FAU - Amore, Rosarita
AU  - Amore R
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy.
FAU - Ricciardi, Walter
AU  - Ricciardi W
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy. Electronic address: wricciardi@rm.unicatt.it.
FAU - Boccia, Stefania
AU  - Boccia S
AD  - Institute of Public Health, Section of Hygiene, Universita Cattolica del Sacro 
      Cuore, Rome 00168, Italy.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140207
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Vaccines)
SB  - IM
MH  - Antibody Formation/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Vaccines/*immunology
OTO - NOTNLM
OT  - Genetic polymorphism
OT  - Human leukocyte antigen
OT  - Immune response
OT  - Meta-analysis
OT  - Systematic review
OT  - Vaccine responsiveness
EDAT- 2014/02/12 06:00
MHDA- 2014/08/21 06:00
CRDT- 2014/02/12 06:00
PHST- 2013/04/30 00:00 [received]
PHST- 2013/12/23 00:00 [revised]
PHST- 2014/01/24 00:00 [accepted]
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/08/21 06:00 [medline]
AID - S0264-410X(14)00109-1 [pii]
AID - 10.1016/j.vaccine.2014.01.057 [doi]
PST - ppublish
SO  - Vaccine. 2014 Mar 26;32(15):1661-9. doi: 10.1016/j.vaccine.2014.01.057. Epub 2014 
      Feb 7.