PMID- 24513109
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 6
DP  - 2014 Jun
TI  - Inherited behaviors, BDNF expression and response to treatment in a novel 
      multifactorial rat model for depression.
PG  - 945-55
LID - 10.1017/S1461145714000030 [doi]
AB  - Major depressive disorder (MDD) is a common and devastating mental illness 
      behaviorally characterized by various symptoms, including reduced motivation, 
      anhedonia and psychomotor retardation. Although the etiology of MDD is still 
      obscure, a genetic predisposition appears to play an important role. Here we 
      used, for the first time, a multifactorial selective breeding procedure to 
      generate a distinct 'depressed' rat line (DRL); our selection was based upon 
      mobility in the forced swim test, sucrose preference and home-cage locomotion, 
      three widely used tests associated with core characteristics of MDD. Other 
      behavioral effects of the selection process, as well as changes in brain-derived 
      neurotrophic factor (BDNF) and the response to three antidepressant treatments, 
      were also examined. We show that decreased mobility in the forced swim test and 
      decreased sucrose preference (two directly selected traits), as well as decreased 
      exploration in the open field test (an indirectly selected trait), are hereditary 
      components in DRL rats. In addition, lower BDNF levels are observed in the dorsal 
      hippocampus of DRL rats, complying with the neurotrophic hypothesis of 
      depression. Finally, electroconvulsive shocks (ECS) but not pharmacological 
      treatment normalizes both the depressive-like behavioral impairments and the 
      BDNF-related molecular alterations in DRL rats, highlighting the need for robust 
      treatment when the disease is inherited and not necessarily triggered by salient 
      chronic stress. We therefore provide a novel multifactorial genetic rat model for 
      depression-related behaviors. The model can be used to further study the etiology 
      of the disease and suggest molecular correlates and possible treatments for the 
      disease.
FAU - Gersner, Roman
AU  - Gersner R
AD  - Department of Life Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
FAU - Gal, Ram
AU  - Gal R
AD  - Department of Life Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
FAU - Levit, Ofir
AU  - Levit O
AD  - Department of Life Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
FAU - Moshe, Hagar
AU  - Moshe H
AD  - Department of Life Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
FAU - Zangen, Abraham
AU  - Zangen A
AD  - Department of Life Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140211
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dietary Sucrose)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder, Major/*physiopathology/*therapy
MH  - Dietary Sucrose/administration & dosage
MH  - *Disease Models, Animal
MH  - Electroconvulsive Therapy
MH  - Feeding Behavior/drug effects/physiology
MH  - Hippocampus/drug effects/physiopathology
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Neuropsychological Tests
MH  - Rats, Sprague-Dawley
MH  - Species Specificity
MH  - Swimming
EDAT- 2014/02/12 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/02/12 06:00
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
AID - S1461145714000030 [pii]
AID - 10.1017/S1461145714000030 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 Jun;17(6):945-55. doi: 
      10.1017/S1461145714000030. Epub 2014 Feb 11.