PMID- 24513264
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20201209
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 84
IP  - 1
DP  - 2014 Apr
TI  - Pulmonary adenosquamous carcinoma with mucoepidermoid carcinoma-like component 
      with characteristic p63 staining pattern: either a novel subtype originating from 
      bronchial epithelium or variant mucoepidermoid carcinoma.
PG  - 45-50
LID - S0169-5002(14)00045-2 [pii]
LID - 10.1016/j.lungcan.2014.01.010 [doi]
AB  - BACKGROUND: Our previous study found unique adenosquamous carcinomas (ADSQs) 
      containing a mucoepidermoid carcinoma (MEC)-like component and a characteristic 
      p63 staining pattern. This study focused on these unique ADSQs. METHODS: Thirty 
      ADSQ cases were studied histologically and by immunohistochemistry for TTF-1 and 
      p63. Of these 30 ADSQs, eight were selected as unique ADSQs. The 
      clinicopathological characteristics of these ADSQs were further studied, and the 
      gene rearrangement of mammalian mastermind-like 2 (MAML2) was investigated by 
      fluorescence in situ hybridization (FISH) for differentiation from pulmonary MEC. 
      RESULTS: The clinicopathological characteristics between the eight ADSQs and the 
      other ADSQ cases showed no statistically significant differences, except for 
      serum CEA level. Histologically, the eight ADSQs contained varying degrees of the 
      MEC-like component, which consisted of solid nests with mucin-filled cysts or a 
      cribriform-like structure. Immunohistochemically, p63-positive nuclei 
      characteristically encircled the tumor nests, although TTF-1 was completely 
      negative. All unique ADSQs not only had a variable degree of squamous cell 
      carcinoma component in addition to the MEC-like component, but also contained a 
      small tubular adenocarcinoma component in three tumors. FISH analysis revealed no 
      MAML2 gene rearrangement in the eight ADSQs. CONCLUSIONS: Of the 30 ADSQs 
      investigated in this study, eight contained a MEC-like component with a 
      characteristic p63 basilar staining pattern similar to that of bronchial basal 
      cells. These unique ADSQs shared clinical characteristics with ordinary ADSQs, 
      but clinicopathologically differed from pulmonary ordinary MEC. Therefore, these 
      unique ADSQs may be either a novel ADSQ subtype originating from bronchial 
      epithelium or variant-type MEC.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Yamatani, Chihiro
AU  - Yamatani C
AD  - Division of Thoracic Surgery, Shizuoka Cancer Center, Japan. Electronic address: 
      y.chi-hi-ro@med.nagoya-u.ac.jp.
FAU - Abe, Masato
AU  - Abe M
AD  - Division of Diagnostic Pathology, Shizuoka Cancer Center, Japan.
FAU - Shimoji, Masaki
AU  - Shimoji M
AD  - Division of Thoracic Surgery, Shizuoka Cancer Center, Japan.
FAU - Maniwa, Tomohiro
AU  - Maniwa T
AD  - Division of Thoracic Surgery, Shizuoka Cancer Center, Japan.
FAU - Takahashi, Shoji
AU  - Takahashi S
AD  - Division of Thoracic Surgery, Shizuoka Cancer Center, Japan.
FAU - Isaka, Mitsuhiro
AU  - Isaka M
AD  - Division of Thoracic Surgery, Shizuoka Cancer Center, Japan.
FAU - Ohde, Yasuhisa
AU  - Ohde Y
AD  - Division of Thoracic Surgery, Shizuoka Cancer Center, Japan.
FAU - Watanabe, Reiko
AU  - Watanabe R
AD  - Division of Diagnostic Pathology, Shizuoka Cancer Center, Japan.
FAU - Ito, Ichiro
AU  - Ito I
AD  - Division of Diagnostic Pathology, Shizuoka Cancer Center, Japan.
FAU - Kondo, Haruhiko
AU  - Kondo H
AD  - Department of Surgery, Kyorin University School of Medicine, Japan.
FAU - Nakajima, Takashi
AU  - Nakajima T
AD  - Division of Diagnostic Pathology, Shizuoka Cancer Center, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140123
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAML2 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (TP63 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Aged
MH  - Carcinoma, Adenosquamous/genetics/*metabolism/*pathology
MH  - Carcinoma, Mucoepidermoid/genetics/metabolism/*pathology
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/genetics/*metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nuclear Proteins/genetics/metabolism
MH  - Risk Factors
MH  - Trans-Activators
MH  - Transcription Factors/genetics/*metabolism
MH  - Tumor Suppressor Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - Adenosquamous carcinoma
OT  - Bronchial basal cell
OT  - Lung cancer
OT  - Mammalian mastermind-like 2
OT  - Mucoepidermoid carcinoma
OT  - p63
EDAT- 2014/02/12 06:00
MHDA- 2014/10/29 06:00
CRDT- 2014/02/12 06:00
PHST- 2013/10/25 00:00 [received]
PHST- 2014/01/10 00:00 [revised]
PHST- 2014/01/15 00:00 [accepted]
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
AID - S0169-5002(14)00045-2 [pii]
AID - 10.1016/j.lungcan.2014.01.010 [doi]
PST - ppublish
SO  - Lung Cancer. 2014 Apr;84(1):45-50. doi: 10.1016/j.lungcan.2014.01.010. Epub 2014 
      Jan 23.