PMID- 24513672
OWN - NLM
STAT- Publisher
LR  - 20240228
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
DP  - 2013 Oct 25
TI  - Donor selection for KIR B haplotype of the centromeric motifs can improve the 
      outcome after HLA-identical sibling hematopoietic stem cell transplantation.
LID - S1083-8791(13)00494-1 [pii]
LID - 10.1016/j.bbmt.2013.10.017 [doi]
AB  - After hematopoietic stem cell transplantation (HSCT), natural killer (NK) cell 
      alloreactivity in human leukocyte antigen (HLA) cell of recipients is regulated 
      by killer immunoglobulin-like receptors (KIRs) on donor NK cells. The effect of 
      KIRs on HSCT outcomes is controversial, particularly in those undergoing 
      HLA-identical sibling HSCT. In this study, effects of KIR and HLA genotypes on 
      the HSCT outcome were investigated in a 5-year retrospective study comprising 219 
      patient-donor pairs undergoing HLA-identical sibling HSCT for myeloid and 
      lymphoid malignancies. We found that 39.7% (87/219) of these pairs who were KIR 
      mismatched had better overall survival (OS) and reduced III-IV acute 
      graft-versus-host disease (aGVHD), especially in acute myeloid leukemia (AML) 
      patients. Bx1 donor KIR genotype with haplotype B on a telomeric region was a 
      risk factor for the OS and relapse-free survival (RFS). Donor centromeric (c) and 
      telomeric (t) KIR haplotype analysis showed that donor KIR cB-tA/tB was 
      associated with improved OS and RFS compared with cA-tA or cA-tB. Furthermore, 
      donor KIR B haplotype of the centromeric motifs (Cen-B) was an independent 
      beneficial factor in improving OS and RFS and in protecting from relapse after 
      HSCT. In AML patients, the occurrence of aGVHD was significantly lower in HLA-C1 
      group compared to that in HLA-C2 group, while such effect was not observed in 
      patients with acute lymphoblastic leukemia or chronic myelogenous leukemia. Our 
      results suggest that KIR could impact outcome and donor KIR haplotype with Cen-B 
      confer significant survival benefits to HLA-identical sibling HSCT.
CI  - (c) 2013 American Society for Blood and Marrow Transplantation.
FAU - Zhou, Huifen
AU  - Zhou H
AD  - Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China.
FAU - Bao, Xiaojing
AU  - Bao X
AD  - Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China.
FAU - Wu, Xiaojin
AU  - Wu X
AD  - Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China.
FAU - Tang, Xiaowen
AU  - Tang X
AD  - Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China.
FAU - Wang, Miao
AU  - Wang M
AD  - Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China.
FAU - Wu, Depei
AU  - Wu D
AD  - Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China. Electronic address: 
      wudepei@medmail.com.cn.
FAU - He, Jun
AU  - He J
AD  - Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of 
      Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of 
      Soochow University, Suzhou, 215006, Jiangsu, P.R.China. Electronic address: 
      junhe1964@163.com.
LA  - eng
PT  - Journal Article
DEP - 20131025
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
OTO - NOTNLM
OT  - Centromeric B
OT  - HSCT
OT  - KIR
OT  - haplotype
OT  - sibling
EDAT- 2014/02/12 06:00
MHDA- 2014/02/12 06:00
CRDT- 2014/02/12 06:00
PHST- 2013/06/06 00:00 [received]
PHST- 2013/10/20 00:00 [accepted]
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - S1083-8791(13)00494-1 [pii]
AID - 10.1016/j.bbmt.2013.10.017 [doi]
PST - aheadofprint
SO  - Biol Blood Marrow Transplant. 2013 Oct 25:S1083-8791(13)00494-1. doi: 
      10.1016/j.bbmt.2013.10.017.