PMID- 24513875
OWN - NLM
STAT- MEDLINE
DCOM- 20141002
LR  - 20220408
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 36
DP  - 2014 Feb
TI  - Hippocampal dysfunctions in tumor-bearing mice.
PG  - 147-55
AB  - Individuals with cancer are particularly susceptible to depression and cognitive 
      impairment. However, the precise mechanisms underlying cancer-induced hippocampal 
      dysfunction are poorly understood. We investigated the effects of a peripheral 
      tumor on emotional behavior, hippocampus-dependent memory and associated 
      molecular and cellular features using an experimental animal model. Behavioral 
      alterations were examined; stress-related parameters measured; hippocampal 
      neurogenesis evaluated; and the levels of pro-inflammatory cytokines, 
      brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (COX-2) assayed, 2 
      weeks after inoculation of adult BALB/c mice with cells of a colon carcinoma cell 
      line (CT26). As the tumors developed, CT26-inoculated mice showed significant 
      increases in the depression-like behavior (measured using the tail suspension 
      test) and memory impairment (in terms of object recognition) compared with 
      vehicle-inoculated controls. The presence of a peripheral tumor significantly 
      elevated the hippocampal levels of mRNAs encoding interleukin-6 (IL-6) and tumor 
      necrosis factor-alpha, as well as plasma IL-6 and corticosterone levels. 
      Additionally, the adrenal glands became enlarged, and the numbers of 
      Ki-67-positive proliferating hippocampal cells and doublecortin-positive immature 
      progenitor neurons, as well as the constitutive levels of mRNAs encoding BDNF and 
      COX-2 were significantly reduced. Therefore, a peripheral tumor alone may be 
      sufficient to induce hippocampal dysfunction, possibly by reducing the rate of 
      neurogenesis and the levels of BDNF and COX-2 in that tissue and also by 
      increasing stress-related parameters and the circulating levels of 
      pro-inflammatory cytokines.
FAU - Yang, Miyoung
AU  - Yang M
FAU - Kim, Juhwan
AU  - Kim J
FAU - Kim, Joong-Sun
AU  - Kim JS
FAU - Kim, Sung-Ho
AU  - Kim SH
FAU - Kim, Jong-Choon
AU  - Kim JC
FAU - Kang, Man-Jong
AU  - Kang MJ
FAU - Jung, Uhee
AU  - Jung U
FAU - Shin, Taekyun
AU  - Shin T
FAU - Wang, Hongbing
AU  - Wang H
FAU - Moon, Changjong
AU  - Moon C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - EC 1.14.99.- (Ptgs2 protein, mouse)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Line, Tumor
MH  - Corticosterone/blood
MH  - Cyclooxygenase 2/metabolism
MH  - Cytokines/blood/metabolism
MH  - Depression/metabolism
MH  - Female
MH  - Hippocampus/*metabolism/pathology
MH  - Inflammation/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasms, Experimental/*metabolism
MH  - Neurogenesis/physiology
MH  - Recognition, Psychology/physiology
MH  - Stress, Physiological
EDAT- 2014/02/12 06:00
MHDA- 2014/10/03 06:00
CRDT- 2014/02/12 06:00
PHST- 2013/07/14 00:00 [received]
PHST- 2013/10/07 00:00 [revised]
PHST- 2013/10/22 00:00 [accepted]
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/10/03 06:00 [medline]
AID - S0889-1591(13)00521-7 [pii]
AID - 10.1016/j.bbi.2013.10.022 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2014 Feb;36:147-55. doi: 10.1016/j.bbi.2013.10.022.