PMID- 2451577
OWN - NLM
STAT- MEDLINE
DCOM- 19880513
LR  - 20190510
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 11
IP  - 3
DP  - 1988 Mar
TI  - Chronic mexiletine therapy for suppression of ventricular arrhythmias.
PG  - 132-6
AB  - One hundred patients with a 70% or greater reduction of ventricular premature 
      contractions (VPCs) from baseline during 12 weeks of mexiletine therapy were 
      continued on treatment for an additional 9 months. Fifteen patients did not have 
      follow-up examinations. The response of the remaining 85 patients during this 
      extended period of open-label mexiletine administration is described. Holter 
      recordings were scheduled at 3-month intervals during this period. At these 
      examinations, between 69 and 80% of patients maintained the same 70% or greater 
      level of VPC suppression observed at the start of the 9-month treatment period. 
      Mean and median levels of VPCs/h at each examination were significantly reduced 
      from premexiletine levels throughout the study (p less than 0.0001). Blood tests 
      and electrocardiographic intervals did not vary. The most frequently used dosage 
      of mexiletine during each 3-month treatment period was 600 mg/day (50.0-55.6% of 
      patients). Side effects warranted discontinuation of therapy in 8% (8/97) of 
      patients, while in 25% (22/85), clinical evaluation resulted in a change in 
      dosage level. Within a setting similar to that of clinical practice, long-term 
      mexiletine administration for non-life-threatening ventricular arrhythmias was 
      effective and well tolerated.
FAU - Duke, M
AU  - Duke M
AD  - Department of Cardiology, Manchester Memorial Hospital, Connecticut.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 1U511HHV4Z (Mexiletine)
SB  - IM
MH  - Cardiac Complexes, Premature/*drug therapy
MH  - Clinical Trials as Topic
MH  - Dose-Response Relationship, Drug
MH  - *Electrocardiography
MH  - Female
MH  - Heart Ventricles/drug effects
MH  - Humans
MH  - Long-Term Care
MH  - Male
MH  - Mexiletine/*therapeutic use
MH  - Middle Aged
MH  - Monitoring, Physiologic
MH  - Tachycardia/drug therapy
EDAT- 1988/03/01 00:00
MHDA- 1988/03/01 00:01
CRDT- 1988/03/01 00:00
PHST- 1988/03/01 00:00 [pubmed]
PHST- 1988/03/01 00:01 [medline]
PHST- 1988/03/01 00:00 [entrez]
AID - 10.1002/clc.4960110304 [doi]
PST - ppublish
SO  - Clin Cardiol. 1988 Mar;11(3):132-6. doi: 10.1002/clc.4960110304.