PMID- 24516755
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140211
LR  - 20211021
IS  - 2075-051X (Print)
IS  - 2075-0528 (Electronic)
IS  - 2075-051X (Linking)
VI  - 14
IP  - 1
DP  - 2014 Feb
TI  - Nasal Allergy and Otitis Media: A real correlation?
PG  - e59-64
AB  - OBJECTIVES: The correlation between middle ear pathology and nasal allergy has 
      been debated for almost 30 years. This study aimed to evaluate the relationship 
      between otitis media with effusion (OME) and persistent allergic rhinitis 
      symptoms versus intermittent rhinitis in children. METHODS: The study included 
      100 atopic children (52 boys, 48 girls) aged 5-9 years with otological symptoms 
      who were patients of the University of Siena Hospital, Italy. Ear, nose and 
      throat evaluations, tympanometry, skin prick tests (SPTs), mucociliary transport 
      time (MCTt) and Eustachian tube function tests were performed. RESULTS: The SPTs 
      revealed 50 children sensitised to Dermatophagoides pteronyssinus, 34 to grass 
      pollen and 16 to Parietaria. Of all patients, mild symptoms were intermittent in 
      19 children and persistent in 18; moderate/severe symptoms were intermittent in 
      22 and persistent in 41. Tubal dysfunction was present in 25 children, whereas 
      middle ear effusion was present in 45 children undergoing myringotomy. The MCTt 
      was slower in the persistent group (21 +/- 2 mins) versus the intermittent group 
      (16 +/- 2 mins) with a significant difference (P <0.01). Mean eosinophil cationic 
      protein (ECP) values in the middle ear effusions of children who had undergone 
      myringotomy were 251 +/- 175.2 mug/L, and mean ECP blood values were 25.5 +/- 16.3 
      mug/L, with significant differences (P < 0.001). CONCLUSION: There was a 
      significant association between OME, delayed MCTt, ECP values in middle ear 
      effusion and persistent symptoms of allergic rhinitis. These results suggest a 
      direct involvement of the middle ear mucosa as a target organ in persistent 
      forms.
FAU - Passali, Desiderio
AU  - Passali D
AD  - Universita di Siena, Siena, Italy;
FAU - Passali, Giulio C
AU  - Passali GC
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy;
FAU - Lauriello, Maria
AU  - Lauriello M
AD  - Universita degli Studi dell'Aquila, L'Aquila, Italy;
FAU - Romano, Antonio
AU  - Romano A
AD  - Universita di Siena, Siena, Italy;
FAU - Bellussi, Luisa
AU  - Bellussi L
AD  - Universita di Siena, Siena, Italy;
FAU - Passali, Francesco M
AU  - Passali FM
AD  - Universita degli Studi di Roma Tor Vergata, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20140127
PL  - Oman
TA  - Sultan Qaboos Univ Med J
JT  - Sultan Qaboos University medical journal
JID - 101519915
PMC - PMC3916278
OTO - NOTNLM
OT  - Children
OT  - Eustachian Tubes
OT  - Genetic Predisposition
OT  - Italy
OT  - Nasal Allergy
OT  - Otitis Media
EDAT- 2014/02/12 06:00
MHDA- 2014/02/12 06:01
PMCR- 2014/02/01
CRDT- 2014/02/12 06:00
PHST- 2012/08/23 00:00 [received]
PHST- 2013/01/19 00:00 [revised]
PHST- 2013/03/20 00:00 [revised]
PHST- 2013/06/18 00:00 [accepted]
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/02/12 06:01 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - squmj1401-e59-64 [pii]
AID - 10.12816/0003337 [doi]
PST - ppublish
SO  - Sultan Qaboos Univ Med J. 2014 Feb;14(1):e59-64. doi: 10.12816/0003337. Epub 2014 
      Jan 27.