PMID- 24516896
OWN - NLM
STAT- MEDLINE
DCOM- 20140808
LR  - 20140210
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 20
IP  - 1
DP  - 2014 Jan
TI  - Impact on outcomes of human leukocyte antigen matching by allele-level typing in 
      adults with acute myeloid leukemia undergoing umbilical cord blood 
      transplantation.
PG  - 106-10
AB  - This retrospective study analyzed the impact of directional donor-recipient human 
      leukocyte antigen (HLA) disparity using allele-level typing at HLA-A, -B, -C, and 
      -DRB1 in 79 adults with acute myeloid leukemia (AML) who received single-unit 
      umbilical cord blood (UCB) transplant at a single institution. With extended 
      high-resolution HLA typing, the donor-recipient compatibility ranged from 2/8 to 
      8/8. HLA disparity showed no negative impact on nonrelapse mortality (NRM), 
      graft-versus-host (GVH) disease or engraftment. Considering disparities in the 
      GVH direction, the 5-year cumulative incidence of relapse was 44% and 22% for 
      patients receiving an UCB unit matched >/= 6/8 and < 6/8, respectively (P = .04). 
      In multivariable analysis, a higher HLA disparity in the GVH direction using 
      extended high-resolution typing (Risk ratio [RR] 2.8; 95% confidence interval 
      [CI], 1.5 to 5.1; P = .0009) and first complete remission at time of 
      transplantation (RR 2.1; 95% CI, 1.2 to 3.8; P = .01) were the only variables 
      significantly associated with an improved disease-free survival. In conclusion, 
      we found that in adults with AML undergoing single-unit UCBT, an increased number 
      of HLA disparities at allele-level typing improved disease-free survival by 
      decreasing the relapse rate without a negative effect on NRM.
FAU - Sanz, Jaime
AU  - Sanz J
FAU - Jaramillo, Francisco J
AU  - Jaramillo FJ
FAU - Planelles, Dolores
AU  - Planelles D
FAU - Montesinos, Pau
AU  - Montesinos P
FAU - Lorenzo, Ignacio
AU  - Lorenzo I
FAU - Moscardo, Federico
AU  - Moscardo F
FAU - Martin, Guillermo
AU  - Martin G
FAU - Lopez, Francisca
AU  - Lopez F
FAU - Martinez, Jesus
AU  - Martinez J
FAU - Jarque, Isidro
AU  - Jarque I
FAU - de la Rubia, Javier
AU  - de la Rubia J
FAU - Larrea, Luis
AU  - Larrea L
FAU - Sanz, Miguel A
AU  - Sanz MA
FAU - Sanz, Guillermo F
AU  - Sanz GF
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (HLA Antigens)
RN  - 0 (Myeloablative Agonists)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - *Cord Blood Stem Cell Transplantation
MH  - Donor Selection
MH  - Female
MH  - Graft Survival
MH  - Graft vs Host Disease/prevention & control
MH  - HLA Antigens/genetics/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*genetics/immunology/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myeloablative Agonists/*therapeutic use
MH  - Recurrence
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tissue Donors
MH  - *Transplantation Conditioning
MH  - Transplantation, Homologous
EDAT- 2014/02/12 06:00
MHDA- 2014/08/13 06:00
CRDT- 2014/02/12 06:00
PHST- 2014/02/12 06:00 [entrez]
PHST- 2014/02/12 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2014 Jan;20(1):106-10.