PMID- 24517419
OWN - NLM
STAT- MEDLINE
DCOM- 20141217
LR  - 20140506
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 39
IP  - 9
DP  - 2014 May
TI  - Task-dependent changes in late inhibitory and disinhibitory actions within the 
      primary motor cortex in humans.
PG  - 1485-90
LID - 10.1111/ejn.12505 [doi]
AB  - The objective of the present study was to investigate the time course of 
      long-interval intracortical inhibition (LICI) and late cortical disinhibition 
      (LCD) as a function of the motor task (index abduction, thumb-index precision 
      grip). Motor-evoked potentials were recorded from the first dorsal interosseus 
      (FDI) muscle of the dominant limb in 13 healthy subjects. We used paired-pulse 
      transcranial magnetic stimulation (TMS) paradigms in which a test pulse was 
      preceded by a suprathreshold priming pulse (130% of the resting motor threshold) 
      with varying interstimulus intervals (ISIs). In each task, double pulses were 
      delivered with ISIs ranging from 30% of the corresponding silent period (SP; ~ 45 
      ms) to 220% of the SP (~ 330 ms). In both tasks, we found that LICI was followed 
      by LCD (namely a period of increased cortical excitability lasting until ~ 200% 
      of the SP). The time-dependent modulation of LICI and LCD differed in the two 
      tasks; LICI was shorter (i.e. disinhibition occurred earlier) and LCD was more 
      intense during precision grip than during index abduction. Long-interval 
      intracortical inhibition disappeared well before the end of the SP in the 
      precision grip task, suggesting that the mechanisms underlying these two 
      inhibitory phenomena are distinct. Our data suggest that disinhibition might 
      reflect adaptation of neural circuit excitability to the functional requirements 
      of the motor task.
CI  - (c) 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Caux-Dedeystere, Alexandre
AU  - Caux-Dedeystere A
AD  - Lille-Nord de France University, Department of Clinical Neurophysiology, EA 4559, 
      Lille University Hospital, Lille Cedex, France.
FAU - Rambour, Melanie
AU  - Rambour M
FAU - Duhamel, Alain
AU  - Duhamel A
FAU - Cassim, Francois
AU  - Cassim F
FAU - Derambure, Philippe
AU  - Derambure P
FAU - Devanne, Herve
AU  - Devanne H
LA  - eng
PT  - Journal Article
DEP - 20140211
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - *Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - *Neural Inhibition
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - disinhibition
OT  - index abduction
OT  - motor control
OT  - precision grip
OT  - transcranial magnetic stimulation
EDAT- 2014/02/13 06:00
MHDA- 2014/12/18 06:00
CRDT- 2014/02/13 06:00
PHST- 2013/10/31 00:00 [received]
PHST- 2014/01/07 00:00 [revised]
PHST- 2014/01/09 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/12/18 06:00 [medline]
AID - 10.1111/ejn.12505 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2014 May;39(9):1485-90. doi: 10.1111/ejn.12505. Epub 2014 Feb 11.