PMID- 24517835
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20211203
IS  - 1600-0781 (Electronic)
IS  - 0905-4383 (Linking)
VI  - 31
IP  - 1
DP  - 2015 Jan
TI  - Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of 
      squamous cell carcinoma and its implication for solid-organ transplant 
      recipients.
PG  - 15-25
LID - 10.1111/phpp.12115 [doi]
AB  - Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United 
      States in immunocompetent patients. Among the solid-organ transplant recipients, 
      NMSCs represent a significant disease burden, and they tend to be multiple and 
      more aggressive. While the precise mechanisms responsible for the higher risk of 
      developing cutaneous squamous cell carcinomas (SCCs) have not been completely 
      elucidated, ultraviolet (UV) light has been established to be critical in 
      initiation and promotion of tumor development. More recently, significant 
      emphasis has been placed on the role of the mammalian target of rapamycin (mTOR) 
      pathway in SCC pathogenesis. Furthermore, some studies have demonstrated the 
      ability of mTOR inhibitors to decrease the incidence of new SCCs in the 
      immunosuppressed transplanted patient population. In this review, we will 
      highlight and examine the most recent available data on the role of UV radiation 
      and its interaction with mTOR pathway signaling in SCC pathogenesis.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Balagula, Yevgeniy
AU  - Balagula Y
AD  - Department of Dermatology, Johns Hopkins Medicine, Baltimore, MD, USA.
FAU - Kang, Sewon
AU  - Kang S
FAU - Patel, Manisha J
AU  - Patel MJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140306
PL  - England
TA  - Photodermatol Photoimmunol Photomed
JT  - Photodermatology, photoimmunology & photomedicine
JID - 9013641
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - *Carcinoma, Squamous Cell/metabolism/pathology
MH  - *Cell Transformation, Neoplastic/metabolism/pathology/radiation effects
MH  - Humans
MH  - *Immunocompromised Host
MH  - *Neoplasm Proteins/immunology/metabolism
MH  - *Organ Transplantation
MH  - *Signal Transduction/immunology/radiation effects
MH  - *Skin Neoplasms/immunology/metabolism/pathology
MH  - *TOR Serine-Threonine Kinases/immunology/metabolism
MH  - Ultraviolet Rays/*adverse effects
OTO - NOTNLM
OT  - NMSC
OT  - mammalian target of rapamycin
OT  - squamous cell carcinoma
OT  - transplant
OT  - ultraviolet radiation
EDAT- 2014/02/13 06:00
MHDA- 2015/09/17 06:00
CRDT- 2014/02/13 06:00
PHST- 2014/01/21 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
AID - 10.1111/phpp.12115 [doi]
PST - ppublish
SO  - Photodermatol Photoimmunol Photomed. 2015 Jan;31(1):15-25. doi: 
      10.1111/phpp.12115. Epub 2014 Mar 6.