PMID- 24517920
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20140416
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 38
DP  - 2014 May
TI  - Postoperative cognitive dysfunction: Involvement of neuroinflammation and 
      neuronal functioning.
PG  - 202-10
LID - S0889-1591(14)00047-6 [pii]
LID - 10.1016/j.bbi.2014.02.002 [doi]
AB  - Postoperative cognitive dysfunction (POCD) has been hypothesized to be mediated 
      by surgery-induced inflammatory processes, which may influence neuronal 
      functioning either directly or through modulation of intraneuronal pathways, such 
      as the brain derived neurotrophic factor (BDNF) mediated pathway. To study the 
      time course of post-surgical (neuro)inflammation, changes in the BDNF-pathway and 
      POCD, we subjected 3months old male Wistar rats to abdominal surgery and 
      implanted a jugular vein catheter for timed blood sampling. Cognition, affective 
      behavior and markers for (neuro)inflammation, BDNF and neurogenesis were assessed 
      at 1, 2 and 3weeks following surgery. Rats displayed changes in exploratory 
      activity shortly after surgery, associated with postoperatively elevated IL-6 
      plasma levels. Spatial learning and memory were temporarily impaired in the first 
      2weeks following surgery, whereas non-spatial cognitive functions seemed 
      unaffected. Analysis of brain tissue revealed increased neuroinflammation (IL-1B 
      and microgliosis) 7days following surgery, decreased BDNF levels on postoperative 
      day 14 and 21, and decreased neurogenesis until at least 21days following 
      surgery. These findings indicate that in young adult rats only spatial learning 
      and memory is affected by surgery, suggesting hippocampal dependent cognition is 
      especially vulnerable to surgery-induced impairment. The observed differences in 
      time course following surgery and relation to plasma IL-6 suggest cognitive 
      dysfunction and mood changes comprise distinct features of postoperative 
      behavioral impairment. The postoperative changes in neuroinflammation, BDNF and 
      neurogenesis may represent aspects of the underlying mechanism for POCD. Future 
      research should be aimed to elucidate how these players interact.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Hovens, Iris B
AU  - Hovens IB
AD  - Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 
      AG Groningen, The Netherlands. Electronic address: I.B.Hovens@rug.nl.
FAU - Schoemaker, Regien G
AU  - Schoemaker RG
AD  - Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 
      AG Groningen, The Netherlands.
FAU - van der Zee, Eddy A
AU  - van der Zee EA
AD  - Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 
      AG Groningen, The Netherlands.
FAU - Absalom, Anthony R
AU  - Absalom AR
AD  - Department of Anesthesiology, University Medical Center Groningen, University of 
      Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
FAU - Heineman, Erik
AU  - Heineman E
AD  - Department of Surgery and Surgical Oncology, University Medical Center Groningen, 
      University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
FAU - van Leeuwen, Barbara L
AU  - van Leeuwen BL
AD  - Department of Surgery and Surgical Oncology, University Medical Center Groningen, 
      University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140208
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Interleukins)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Cognition Disorders/*etiology
MH  - Encephalitis/*complications
MH  - Exploratory Behavior
MH  - Interleukins/metabolism
MH  - Male
MH  - Maze Learning
MH  - Microglia/metabolism
MH  - *Postoperative Complications
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Exploratory behavior
OT  - Learning and memory
OT  - Neurogenesis
OT  - Neuroinflammation
OT  - Postoperative cognitive dysfunction
OT  - Surgery
EDAT- 2014/02/13 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/13 06:00
PHST- 2013/11/06 00:00 [received]
PHST- 2014/01/27 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0889-1591(14)00047-6 [pii]
AID - 10.1016/j.bbi.2014.02.002 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2014 May;38:202-10. doi: 10.1016/j.bbi.2014.02.002. Epub 2014 
      Feb 8.