PMID- 2451815
OWN - NLM
STAT- MEDLINE
DCOM- 19880524
LR  - 20131121
IS  - 0032-5473 (Print)
IS  - 0032-5473 (Linking)
VI  - 63 Suppl 3
DP  - 1987
TI  - The analgesic efficacy of flupirtine in comparison to pentazocine and placebo 
      assessed by EEG and subjective pain ratings.
PG  - 109-12
AB  - In a placebo-controlled double-blind study the analgesic efficacy of the 
      non-narcotic analgesic flupirtine (80 mg i.v.) was evaluated in comparison with 
      the opioid pentazocine (30 mg i.v.). The variables investigated were the 
      subjects' pain ratings (E), the somatosensory evoked cerebral potentials (SEP), 
      the auditory evoked potentials (AEP) and the power spectral density of the 
      ongoing EEG (PSD). One stimulus block before (PRE) and one stimulus block after 
      (POST) medication were applied. In one stimulus block 80 intracutaneous 
      electrical stimuli of two- and three-fold pain threshold amperage were given in 
      randomized order of intensity and inter-stimulus intervals. Both treatments 
      reduced the subjects' pain ratings significantly, while the placebo values were 
      constant. These effects on pain ratings were in parallel with the SEP changes. 
      The peak-to-peak amplitudes of the late components were significantly diminished 
      by both drugs. Placebo had no effect on this variable. The AEPs remained 
      considerably constant after all three treatments indicating specific drug effect 
      on the pain-related somatosensory pathways. Flupirtine showed effects similar to 
      those of pentazocine in terms of pain relief. The changes in ongoing EEG 
      activity, however, were of a different kind. Pentazocine changed the EEG in an 
      opiate-like manner, while flupirtine increased relative power in the theta and 
      beta range.
FAU - Bromm, B
AU  - Bromm B
AD  - Institute of Physiology, University of Hamburg, University Hospital Eppendorf, 
      FRG.
FAU - Ganzel, R
AU  - Ganzel R
FAU - Herrmann, W M
AU  - Herrmann WM
FAU - Meier, W
AU  - Meier W
FAU - Scharein, E
AU  - Scharein E
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Aminopyridines)
RN  - 0 (Analgesics)
RN  - MOH3ET196H (flupirtine)
RN  - RP4A60D26L (Pentazocine)
SB  - IM
MH  - Aminopyridines/*pharmacology
MH  - Analgesics/*pharmacology
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/drug effects
MH  - Evoked Potentials, Somatosensory/drug effects
MH  - Humans
MH  - Male
MH  - Pain/psychology
MH  - Pain Measurement/methods
MH  - *Palliative Care
MH  - Pentazocine/therapeutic use
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Postgrad Med J. 1987;63 Suppl 3:109-12.