PMID- 24518228
OWN - NLM
STAT- MEDLINE
DCOM- 20140910
LR  - 20151119
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 25
IP  - 4
DP  - 2014 Mar 5
TI  - 4-Methylcatechol prevents derangements of brain-derived neurotrophic factor and 
      TrkB-related signaling in anterior cingulate cortex in chronic pain with 
      depression-like behavior.
PG  - 226-32
LID - 10.1097/WNR.0000000000000072 [doi]
AB  - Chronic pain with mood disorder, resulting from a peripheral nerve injury, is a 
      serious clinical problem affecting the quality of life. A lack of brain-derived 
      neurotrophic factor (BDNF) and abnormal intercellular signaling in the brain can 
      mediate this symptom. BDNF is induced in cultured neurons by 4-methylcatechol 
      (4-MC), but little is known about its role in pain-emotion. Thus, we 
      characterized the actions of 4-MC on TrkB receptor-related pERK and BDNF mRNA in 
      discreet brain regions related to pain-emotion after chronic pain in rat. Rats 
      implanted with a stainless steel cannula into the lateral ventricular were 
      subjected to chronic constriction injury (CCI). Pain was assessed by changes in 
      paw withdrawal latency (PWL) to heat stimuli after CCI. Immobility time during 
      the forced swimming testing was measured for depression-like behavior. Analgesic 
      and antidepression modulations with 4-MC were examined by an anti-BDNF antibody 
      (K252a, a TrkB receptor inhibitor). The animals were perfused and fixed (4% 
      paraformaldehyde) for immunohistochemistry analysis (c-FOS/pERK). BDNF mRNA 
      expression (anterior cingulate cortex) was determined using reverse 
      transcription-PCR. Rats showed a sustained decrease in PWL, associated with a 
      prolonged immobility time after CCI. 4-MC reduced decreases in PWL and increased 
      immobility time. 4-MC reduced increases in pERK immunoreactivity and decreases in 
      BDNF mRNA expression in regions related to pain and the limbic system. Anti-BDNF 
      blocked effects induced by 4-MC. We suggest that a lack of BDNF associated with 
      activated extracellular signal-regulated kinase in the pain-emotion network may 
      be involved in depression-like behavior during chronic pain. 4-MC ameliorates 
      pain-emotion symptoms by inducing BDNF and normalizing pERK activities.
FAU - Ishikawa, Kozo
AU  - Ishikawa K
AD  - aDepartment of Laboratory Sciences, Division of Neurosciences Departments of 
      bNeurosciences cPsychology, Yamaguchi University Graduate School of Medicine 
      dDepartment of Food and Nutrition, Ube Frontier College, Yamaguchi eDepartment of 
      2nd Anatomy, Sapporo Medical University, Sapporo fDepartment of Nursing, Faculty 
      of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Japan.
FAU - Yasuda, Seiko
AU  - Yasuda S
FAU - Fukuhara, Kayoko
AU  - Fukuhara K
FAU - Iwanaga, Yasutake
AU  - Iwanaga Y
FAU - Ida, Yuika
AU  - Ida Y
FAU - Ishikawa, Junko
AU  - Ishikawa J
FAU - Yamagata, Hirotaka
AU  - Yamagata H
FAU - Ono, Midori
AU  - Ono M
FAU - Kakeda, Takahiro
AU  - Kakeda T
FAU - Ishikawa, Toshizo
AU  - Ishikawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Analgesics)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Catechols)
RN  - 0 (RNA, Messenger)
RN  - 12GLI7JGB3 (4-methylcatechol)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Analgesics/*therapeutic use
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Catechols/*therapeutic use
MH  - Chronic Pain/complications/*drug therapy/metabolism
MH  - Depression/complications/*drug therapy/metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Gyrus Cinguli/drug effects/metabolism
MH  - Hot Temperature
MH  - Hyperalgesia/complications/drug therapy/metabolism
MH  - Nerve Compression Syndromes
MH  - Neuropsychological Tests
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/antagonists & inhibitors/metabolism
MH  - Sciatic Nerve
MH  - Signal Transduction/drug effects
EDAT- 2014/02/13 06:00
MHDA- 2014/09/11 06:00
CRDT- 2014/02/13 06:00
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/09/11 06:00 [medline]
AID - 00001756-201403050-00005 [pii]
AID - 10.1097/WNR.0000000000000072 [doi]
PST - ppublish
SO  - Neuroreport. 2014 Mar 5;25(4):226-32. doi: 10.1097/WNR.0000000000000072.