PMID- 24520190
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140212
LR  - 20211021
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 8
DP  - 2014
TI  - Spectral-domain optical coherence tomographic and fundus autofluorescence 
      findings in eyes with primary intraocular lymphoma.
PG  - 335-41
LID - 10.2147/OPTH.S58114 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate the findings on 
      spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence 
      (FAF) in three eyes with primary intraocular lymphoma (PIOL). METHODS: The 
      medical records of three eyes from three patients with biopsy-proven PIOL and 
      retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic 
      findings were evaluated in the three eyes and FAF images in two eyes. RESULTS: 
      The PIOL in the three patients was monocular. Vitreous opacities and retinal 
      infiltrations were observed in the three eyes, and iritis was present in two 
      eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. 
      The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor 
      of the three eyes. The FAF images for two eyes showed abnormal granular 
      hyperautofluorescence and hypoautofluorescence which were the reverse of the 
      pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed 
      hyper-reflective infiltrations at the level of the retinal pigment epithelium 
      (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, 
      disruption of the photoreceptor inner segment/outer segment junction, and 
      multiple hyper-reflective signals in the inner retina. CONCLUSION: Because of the 
      characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that 
      these noninvasive methods may be used for a rapid diagnosis of PIOL and also for 
      understanding the pathology of PIOL.
FAU - Egawa, Mariko
AU  - Egawa M
AD  - Department of Ophthalmology, Institute of Health Biosciences, The University of 
      Tokushima Graduate School, Tokushima, Japan.
FAU - Mitamura, Yoshinori
AU  - Mitamura Y
AD  - Department of Ophthalmology, Institute of Health Biosciences, The University of 
      Tokushima Graduate School, Tokushima, Japan.
FAU - Hayashi, Yuki
AU  - Hayashi Y
AD  - Department of Ophthalmology, Institute of Health Biosciences, The University of 
      Tokushima Graduate School, Tokushima, Japan.
FAU - Naito, Takeshi
AU  - Naito T
AD  - Department of Ophthalmology, Institute of Health Biosciences, The University of 
      Tokushima Graduate School, Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140131
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC3917953
OTO - NOTNLM
OT  - fundus autofluorescence
OT  - primary intraocular lymphoma
OT  - spectral-domain optical coherence tomography
EDAT- 2014/02/13 06:00
MHDA- 2014/02/13 06:01
PMCR- 2014/01/31
CRDT- 2014/02/13 06:00
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/02/13 06:01 [medline]
PHST- 2014/01/31 00:00 [pmc-release]
AID - opth-8-335 [pii]
AID - 10.2147/OPTH.S58114 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2014 Jan 31;8:335-41. doi: 10.2147/OPTH.S58114. eCollection 
      2014.