PMID- 24520258
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 7
IP  - 3
DP  - 2014 Mar
TI  - Efficacy analysis of three-year subcutaneous SQ-standardized specific 
      immunotherapy in house dust mite-allergic children with asthma.
PG  - 630-634
AB  - The present study aimed to evaluate the efficacy of three-year subcutaneous 
      SQ-standardized specific immunotherapy (SCIT) in house dust mite (HDM)-allergic 
      children with asthma. Ninety children with allergic asthma to HDMs, with or 
      without allergic rhinitis, were randomly divided into two groups, the treatment 
      group and the control group. The treatment group received SCIT combined with 
      standardized glucocorticoid management and the control group received 
      standardized glucocorticoid management alone for a period of three years. The 
      mean daily dose of inhaled corticosteroids (ICSs), a four-week diary recording 
      the symptom scores of asthma, peak expiratory flow (PEF) measurements, skin prick 
      test results and serum immunoglobulin E (IgE) levels were assessed prior to 
      treatment and following one, two and three years of treatment. The median dose of 
      ICS was reduced in the treatment group after two and three years of treatment 
      compared with that of the control group. After three years of treatment, the 
      discontinuation percentage of ICS in the treatment group was higher than that in 
      the control group. The treatment group demonstrated significantly reduced daytime 
      and night-time asthmatic symptom scores, increased PEF values and reduced serum 
      IgE levels after two and three years of treatment compared with those in the 
      control group (P<0.05). In conclusion, three-year SCIT treatment combined with 
      ICS is an effective immunotherapy for children with allergic asthma and resulted 
      in a reduction of the required ICS dose.
FAU - Hui, Yu
AU  - Hui Y
AD  - Department of Respiratory Medicine, Wuxi Children's Hospital Affiliated to 
      Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
FAU - Li, Ling
AU  - Li L
AD  - Department of Respiratory Medicine, Wuxi Children's Hospital Affiliated to 
      Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
FAU - Qian, Jun
AU  - Qian J
AD  - Department of Respiratory Medicine, Wuxi Children's Hospital Affiliated to 
      Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
FAU - Guo, Yun
AU  - Guo Y
AD  - Department of Respiratory Medicine, Wuxi Children's Hospital Affiliated to 
      Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
FAU - Zhang, Xilian
AU  - Zhang X
AD  - Department of Respiratory Medicine, Wuxi Children's Hospital Affiliated to 
      Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
FAU - Zhang, Xiaojuan
AU  - Zhang X
AD  - Department of Respiratory Medicine, Wuxi Children's Hospital Affiliated to 
      Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140102
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3919950
OTO - NOTNLM
OT  - SQ-standardized specific immunotherapy
OT  - asthma
OT  - children
OT  - house dust mite
OT  - inhaled corticosteroids
EDAT- 2014/02/13 06:00
MHDA- 2014/02/13 06:01
PMCR- 2014/01/02
CRDT- 2014/02/13 06:00
PHST- 2013/07/24 00:00 [received]
PHST- 2013/11/27 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/02/13 06:01 [medline]
PHST- 2014/01/02 00:00 [pmc-release]
AID - etm-07-03-0630 [pii]
AID - 10.3892/etm.2014.1469 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Mar;7(3):630-634. doi: 10.3892/etm.2014.1469. Epub 2014 Jan 2.