PMID- 24520281
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 7
IP  - 3
DP  - 2014 Mar
TI  - Chronic lipopolysaccharide exposure induces cognitive dysfunction without 
      affecting BDNF expression in the rat hippocampus.
PG  - 750-754
AB  - Previous studies have shown that lipopolysaccharide (LPS) has the potential to 
      cause cognitive dysfunction. However, the underlying pathogenesis has yet to be 
      fully elucidated. Increasing attention is being focused on infection in the 
      central nervous system. Therefore, the present study aimed to investigate the 
      behavioral performance of rats receiving intraperitoneal injections of LPS and to 
      determine the expression levels of amyloid-beta (Abeta), brain-derived neurotrophic 
      factor (BDNF) and pro-inflammatory cytokines in the hippocampus. In total, 30 
      male Wistar rats were randomly divided into 3 groups (each n=10): Control and 3 
      and 7 day LPS administration groups. The rats were intraperitoneally injected 
      with saline or LPS for 3 or 7 days. Following this, rats performed the Morris 
      water maze test, in which the latency to the platform and proportion of time 
      spent in the target quadrant were recorded. Rats were then sacrificed and the 
      hippocampi were harvested for determination of interleukin (IL)-1beta, IL-6, tumor 
      necrosis factor-alpha (TNF-alpha), Abeta and BDNF expression levels. LPS administration for 
      3 and 7 days significantly increased the latency to the platform and decreased 
      the proportion of time spent in the target quadrant compared with those in the 
      control group, (P<0.05). Administration of LPS for 3 and 7 days induced 
      statistically significant increases in the expression levels of IL-1beta, IL-6 and 
      TNF-alpha in the hippocampus, compared with those in the control group (P<0.05). 
      Additionally, the administration of LPS for 7 days induced a statistically 
      significant increase in the expression level of Abeta in the hippocampus, compared 
      with that in the control group (P<0.05). However, the administration of LPS did 
      not elicit a statistically significant change in the expression level of BDNF in 
      the hippocampus, compared with that in the control group (P>0.05). The results 
      indicate that LPS induces cognitive dysfunction, which is associated with 
      increased expression levels of pro-inflammatory cytokines and Abeta, but does not 
      affect the expression of BDNF in the hippocampus.
FAU - Zhu, Bin
AU  - Zhu B
AD  - Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
FAU - Wang, Zhi-Gang
AU  - Wang ZG
AD  - Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
FAU - Ding, Jie
AU  - Ding J
AD  - Department of Anesthesiology, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
FAU - Liu, Ning
AU  - Liu N
AD  - Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
FAU - Wang, DA-Ming
AU  - Wang DM
AD  - Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
FAU - Ding, Liang-Cai
AU  - Ding LC
AD  - Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
FAU - Yang, Chun
AU  - Yang C
AD  - Department of Anesthesiology, The Third Affiliated Hospital of Soochow 
      University, Changzhou, Jiangsu 213003, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140108
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3919865
OTO - NOTNLM
OT  - amyloid-beta
OT  - brain-derived neurotrophic factor
OT  - cognitive dysfunction
OT  - lipopolysaccharide
OT  - pro-inflammatory cytokines
EDAT- 2014/02/13 06:00
MHDA- 2014/02/13 06:01
PMCR- 2014/01/08
CRDT- 2014/02/13 06:00
PHST- 2013/08/13 00:00 [received]
PHST- 2014/01/02 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/02/13 06:01 [medline]
PHST- 2014/01/08 00:00 [pmc-release]
AID - etm-07-03-0750 [pii]
AID - 10.3892/etm.2014.1479 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Mar;7(3):750-754. doi: 10.3892/etm.2014.1479. Epub 2014 Jan 8.