PMID- 24520320
OWN - NLM
STAT- MEDLINE
DCOM- 20141013
LR  - 20211203
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - New susceptibility and resistance HLA-DP alleles to HBV-related diseases 
      identified by a trans-ethnic association study in Asia.
PG  - e86449
LID - 10.1371/journal.pone.0086449 [doi]
LID - e86449
AB  - Previous studies have revealed the association between SNPs located on human 
      leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic 
      hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or 
      haplotypes associated with chronic HBV infection or disease progression have not 
      been fully identified in Asian populations. We performed trans-ethnic association 
      analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus 
      infection and disease progression among Asian populations comprising Japanese, 
      Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP 
      and chronic HBV infection and disease progression, we conducted high-resolution 
      (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including 
      HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic 
      association analyses among Asian populations identified a new risk allele 
      HLA-DPB1*09 ratio 01 (P = 1.36 x 10(-6); OR= 1.97; 95% CI, 1.50-2.59) and a new 
      protective allele DPB1*02 ratio 01 (P = 5.22 x 10(-6); OR = 0.68; 95% CI, 0.58-0.81) 
      to chronic HBV infection, in addition to the previously reported alleles. 
      Moreover, DPB1*02 ratio 01 was also associated with a decreased risk of disease 
      progression in chronic HBV patients among Asian populations (P = 1.55 x 10(-7); 
      OR = 0.50; 95% CI, 0.39-0.65). Trans-ethnic association analyses identified 
      Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection 
      or disease progression. The present findings will serve as a base for future 
      functional studies of HLA-DP molecules in order to understand the pathogenesis of 
      HBV infection and the development of hepatocellular carcinoma.
FAU - Nishida, Nao
AU  - Nishida N
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan ; Department of Human Genetics, 
      Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Sawai, Hiromi
AU  - Sawai H
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Kashiwase, Koichi
AU  - Kashiwase K
AD  - HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 
      Koutou-ku, Tokyo, Japan.
FAU - Minami, Mutsuhiko
AU  - Minami M
AD  - HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 
      Koutou-ku, Tokyo, Japan.
FAU - Sugiyama, Masaya
AU  - Sugiyama M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan.
FAU - Seto, Wai-Kay
AU  - Seto WK
AD  - Department of Medicine, Queen Mary Hospital, Hong Kong.
FAU - Yuen, Man-Fung
AU  - Yuen MF
AD  - Department of Medicine, Queen Mary Hospital, Hong Kong.
FAU - Posuwan, Nawarat
AU  - Posuwan N
AD  - Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Poovorawan, Yong
AU  - Poovorawan Y
AD  - Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Ahn, Sang Hoon
AU  - Ahn SH
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 
      South Korea.
FAU - Han, Kwang-Hyub
AU  - Han KH
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 
      South Korea.
FAU - Matsuura, Kentaro
AU  - Matsuura K
AD  - Department of Virology & Liver Unit, Nagoya City University Graduate School of 
      Medical Sciences, Nagoya, Aichi, Japan.
FAU - Tanaka, Yasuhito
AU  - Tanaka Y
AD  - Department of Virology & Liver Unit, Nagoya City University Graduate School of 
      Medical Sciences, Nagoya, Aichi, Japan.
FAU - Kurosaki, Masayuki
AU  - Kurosaki M
AD  - Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 
      Musashino, Tokyo, Japan.
FAU - Asahina, Yasuhiro
AU  - Asahina Y
AD  - Department of Liver Disease Control, Tokyo Medical and Dental University, 
      Bunkyo-ku, Tokyo, Japan ; Department of Gastroenterology and Hepatology, Tokyo 
      Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
FAU - Izumi, Namiki
AU  - Izumi N
AD  - Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 
      Musashino, Tokyo, Japan.
FAU - Kang, Jong-Hon
AU  - Kang JH
AD  - Department of Internal Medicine, Teine Keijinkai Hospital, Sapporo, Hokkaido, 
      Japan.
FAU - Hige, Shuhei
AU  - Hige S
AD  - Department of Internal Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Hokkaido, Japan.
FAU - Ide, Tatsuya
AU  - Ide T
AD  - Division of Gastroenterology, Department of Medicine, Kurume University School of 
      Medicine, Kurume, Fukuoka, Japan.
FAU - Yamamoto, Kazuhide
AU  - Yamamoto K
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School 
      of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Okayama, Japan.
FAU - Sakaida, Isao
AU  - Sakaida I
AD  - Gastroenterology and Hepatology, Yamaguchi University Graduate School of 
      Medicine, Ube, Yamaguchi, Japan.
FAU - Murawaki, Yoshikazu
AU  - Murawaki Y
AD  - Faculty of Medicine, Tottori University, Tottori, Tottori, Japan.
FAU - Itoh, Yoshito
AU  - Itoh Y
AD  - Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of 
      Medicine, Kyoto, Kyoto, Japan.
FAU - Tamori, Akihiro
AU  - Tamori A
AD  - Department of Hepatology, Osaka City University Graduate School of Medicine, 
      Osaka, Osaka, Japan.
FAU - Orito, Etsuro
AU  - Orito E
AD  - Department of Gastroenterology, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, 
      Japan.
FAU - Hiasa, Yoichi
AU  - Hiasa Y
AD  - Department of Gastroenterology and Metabology, Ehime University Graduate School 
      of Medicine, Toon, Ehime, Japan.
FAU - Honda, Masao
AU  - Honda M
AD  - Department of Gastroenterology, Kanazawa University Graduate School of Medicine, 
      Kanazawa, Ishikawa, Japan.
FAU - Kaneko, Shuichi
AU  - Kaneko S
AD  - Department of Gastroenterology, Kanazawa University Graduate School of Medicine, 
      Kanazawa, Ishikawa, Japan.
FAU - Mita, Eiji
AU  - Mita E
AD  - Department of Gastroenterology and Hepatology, National Hospital Organization 
      Osaka National Hospital, Osaka, Osaka, Japan.
FAU - Suzuki, Kazuyuki
AU  - Suzuki K
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medcine, 
      Iwate Medical University, Morioka, Iwate, Japan.
FAU - Hino, Keisuke
AU  - Hino K
AD  - Division of Hepatology and Pancreatology, Kawasaki Medical College, Kurashiki, 
      Okayama, Japan.
FAU - Tanaka, Eiji
AU  - Tanaka E
AD  - Department of Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, 
      Japan.
FAU - Mochida, Satoshi
AU  - Mochida S
AD  - Division of Gastroenterology and Hepatology, Saitama Medical University, Iruma, 
      Saitama, Japan.
FAU - Watanabe, Masaaki
AU  - Watanabe M
AD  - Department of Gastroenterology, Kitasato University School of Medicine, 
      Sagamihara, Kanagawa, Japan.
FAU - Eguchi, Yuichiro
AU  - Eguchi Y
AD  - Department of Internal Medicine, Saga Medical School, Saga, Saga, Japan.
FAU - Masaki, Naohiko
AU  - Masaki N
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan.
FAU - Murata, Kazumoto
AU  - Murata K
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan.
FAU - Korenaga, Masaaki
AU  - Korenaga M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan.
FAU - Mawatari, Yoriko
AU  - Mawatari Y
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan.
FAU - Ohashi, Jun
AU  - Ohashi J
AD  - Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
FAU - Kawashima, Minae
AU  - Kawashima M
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Mizokami, Masashi
AU  - Mizokami M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, Ichikawa, Chiba, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140210
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-DP Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Asia
MH  - Disease Resistance/*genetics/immunology
MH  - Ethnicity/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-DP Antigens/genetics
MH  - Haplotypes/genetics
MH  - Hepatitis B/*genetics/immunology
MH  - Hepatitis B virus/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3919706
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/02/13 06:00
MHDA- 2014/10/14 06:00
PMCR- 2014/02/10
CRDT- 2014/02/13 06:00
PHST- 2013/11/13 00:00 [received]
PHST- 2013/12/10 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2014/02/13 06:00 [pubmed]
PHST- 2014/10/14 06:00 [medline]
PHST- 2014/02/10 00:00 [pmc-release]
AID - PONE-D-13-45833 [pii]
AID - 10.1371/journal.pone.0086449 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 10;9(2):e86449. doi: 10.1371/journal.pone.0086449. eCollection 
      2014.